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Faculty Information

Daniel Malamud, PhD

Professor of Basic Science, NYU College of Dentistry
Professor of Medicine (Infectious Diseases), NYU School of Medicine
Director of HIV/AIDS Research Program (HARP), NYU College of Dentistry.
Basic Science and Craniofacial Biology
Room 917S Dental Center, 421 First Avenue
Fax: 212-995-4362
E-mail: daniel.malamud@nyu.edu

Education

PhD, Cell Biology, University of Cincinnati 1965
BS, Biology, University of Michigan 1961

Honors/Credentials

  • Research Career Development Award 1972-1977
  • Fulbright-Hays Senior Lecturer 1975
  • Basic Science Teaching Award 1988
  • Lindback Teaching Award 1992
  • Research Career Development Award 1972-1977
  • NYSTAR Distinguished Professor Award 2005-2008

Research Interests / Professional Overview

Research Interests

My research projects are focused in three major areas: (1) Development of microfluidic point-of-care diagnostic tests for HIV, TB and Malaria utilizing blood and saliva samples; (2) Role of DMBT1 (aka gp340, SAG) in HIV pathogenesis and designing a novel anti-viral molecule based on the active gp120 binding domain of this glycoprotein; (3) Discovery of plasma and salivary biomarkers for medical conditions including HIV, chronic depression, and pain.

Academic Positions

  • 1970-1977 Assistant Professor of Pathology, Department of Surgery, Harvard Medical School/Massachusetts General Hospital
  • 1977-1984 Associate Professor of Biochemistry, University of Pennsylvania School of Dental

Medicine

  • 1985-1992 Chair Department of Biochemistry University of Pennsylvania School of Dental Medicine
  • 1984-2005 Professor, Department of Biochemistry, University of Pennsylvania School of Dental Medicine
  • 2005- Professor, Department oif Basic Sciences, NYU College of Dentistry
  • 2006- Professor of Medicine, NYU School of Medicine

Current Funding

  • U19DE018385 Crosstalk among oral & gastrointe3stinal soluble innate factor, HIV, & microbes.
  • R4DE024456 Point-of-care detectiuon of HIV antibodies and RNA in blood and saliva
  • RO1 AI1082701 Role of gp340 in mucosal HIV-1 transmission and inhibition

Representative Publications

Complete listing available on the NYU Health Sciences Library site.

Search PubMed for articles.

Hill JM, Stern EM, Bhattacharjee PS, Malamud D, Clement C, Rodriguez P, Lukiw WJ, Ochoa AC, Foster TP, Velasco C, McFerrin HE Jr. 2013, The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model. Antiviral Res. 2013 100:14-19.

Barber C, Weissman D, Barnhart K, Dalvi M, Abrams WR, Malamud D. 2013. An Electrochemiluminescent Assay for gp340 (DMBT1). Anal Biochem. 440:78-80.

Zhang, N, Zhang, Z, Feng, S, Wang, Q, Malamud, D, Deng, H. 2013 Quantitative analysis of differentially expressed saliva proteins in human immunodeficiency virus type 1 (HIV-1) infected individuals. Anal. Chim Acta 774:61-66.

Ongagna-Yhombi SY, Corstjens P, Geva E, Abrams WR, Barber CA, Malamud D, Mharakurwa S. 2013. Improved assay to detect Plasmodium falciparum using an uninterrupted, semi-nested PCR and quantitative lateral flow analysis. Malaria J 12:74-82

Corstjens, PL, Abrams, WR, Malamud, D. 2012 Detecting viruses by using salivary diagnostics. J Am Dent Assoc. 143: (10 suppl) 12S-8S.

Saxena, D, Li, Y, Yang, L, Pei, Z, Poles, M, Malamud, D. 2012. Human microbiome and HIV/AIDS. Current HIV/AIDS Rep. 9:44-51.

Malamud D, Abrams WR, Barber CA, Weissman D, Rehnatz M, Golub E. 2011. Antiviral activities in human saliva. Adv Dent Res 23:34-37.

Malamud, D. 2011. Saliva as a Diagnostic Fluid. Dent Clin. North Am. 55:159-178.

Malamud D, Wahl SM. 2010. The mouth: a gateway or a trap for HIV? AIDS 2;24(1):5-16

Stoddard E, Ni H, Cannon G, Zhou C, Kallenbach N, Malamud D, Weissman D. 2009. gp340 promotes transcytosis of human immunodeficiency virus type 1 in genital tract-derived cell lines and primary endocervical tissue. J Virol. 83(17):8596-603.

Liu C, Qiu X, Ongagna S, Chen D, Chen Z, Abrams WR, Malamud D, Corstjens PL, Bau HH. 2009. A timer-actuated immunoassay cassette for detecting molecular markers in oral fluids. Lab Chip. 2009 Mar 21;9(6):768-76.

Stoddard E, Cannon G, Ni H, Karikó K, Capodici J, Malamud D, Weissman D. 2007. gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission. J Immunol. 1;179(5):3126-32.

Malamud, D, Niedbala, RS. 2007. Oral-based Diagnostics. Annals NY Academy of Sciences. Volume 1098.

Stoddard E, Cannon G, Ni H, Karikó K, Capodici J, Malamud D, Weissman D. (2007)
J Immunol.179(5):3126-32.PMID: 17709527 gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission.

Cannon, G, Yi, (2008), Stoddard, E, Scales, DA, Van Ryk, DI, Chaiken, I, Malamud, D, Weissman, D. HIV envelope binding by macrophage-expressed gp340 promotes HIV-1 infection. J Immunol; 181:2065-2070.

Stoddard, E, Cannon, G, Ni, H, Kariko, K, Capodici, J, Malamud, D, Weissman, D. (2007) gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission. J Immunol; 179:3126-3132.

Chen, Z, Mauk, MG, (2007), J, Abrams, WR, Corstjens, PL, Niedbala, RS, Malamud, D, Bau, HH. A microfluidic system for saliva-based detection of infectious diseases. Ann NY Acad Sci 1098:429-436.

Malamud, D, Abrams, WR, Bau HH, Wang, J, Chen, Z, Corstjens, P, Niedbala, RS. , (2006) Oral-based techniques for the diagnosis of infectious diseases. J Calif Dent Assoc 34(4):297-301.
Malamud, D, Bau H, Niedbala S, Corstjens P. Point detection of pathogens in oral samples. Adv Dent Res. (2005); 18(1): 12-6.

Slaughter YA, Malamud D. (2005) diagnostics for the geriatric populations: current status and future prospects. Dent Clin North Am.;49(2):445-61.

Barnhart KT, Pretorius ES, Timbers K, Shera D, Shabbout M, Malamud D. (2004) In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercouse. Contraception. 70(6):498-505.

Holm-Hansen C, Tong G, Davis C, Abrams WR, Malamud D. Comparison of oral fluid collectors for use in a rapid point-of-care diagnostic device. Clin Diagn Lab Immunol. 2004 Sep;11(5):909-12.

Wu Z, Golub E, Abrams WR, Malamud D. gp340 (SAG) binds to the V3 sequence of gp120 important for chemokine receptor interaction. AIDS Res Hum Retroviruses. 2004 Jun;20(6):600-7.

Wu Z, Van Ryk D, Davis C, Abrams WR, Chaiken I, Magnani J, Malamud D. Salivary agglutinin inhibits HIV type 1 infectivity through interaction with viral glycoprotein 120. AIDS Res Hum Retroviruses. 2003 Mar;19(3):201-9.

Pretorius ES, Timbers K, Malamud D, Barnhart K. Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourse. Contraception. 2002 Dec;66(6):443-51.

Malamud, D., Davis, C., Berthold, P., Roth, E., and Freidman, H.A. (1993) Human Submandibular Saliva Aggregates HIV. AIDS Research Human Retro. 9:633 637.

Malamud, D. and Tabak, L., (1993) Saliva as a diagnostic fluid. Annals NY Academy of Sciences Volume 694.

Pearce Pratt, R, Malamud, D. and Phillips, D.M. (1994) Role of the Cytoskeleton in Cell to Cell Transmission of Human Immunodeficiency Virus. J. Virology 68:2898 2905.