345 E. 24th Street, 4W, New York, NY 10010
Certificate, Prosthodontics, Harvard University 2007
MMSc, Oral Biology, Harvard University 2007
DMD, Dental Medicine, University of Pennsylvania 2004
Postdoc, Gene therapy, National Institutes of Health 2002
PhD, Immunology/Microbiology, Tokyo Medical University 1994
DDS, Dentistry, Nihon University 1990
Dr. Yamano conducts translational research as a clinician/scientist. The long-term goal of his research program is that his studies will benefit patients with advanced prosthodontic treatment needs. Currently, Dr. Yamano's lab investigates three major areas: (1) utilization of efficient non-viral vectors for gene therapy, (2) growth factor protein delivery using collagen membranes for bone regeneration, and (3) molecular analysis of osseointegration for novel implant surfaces. Recently, his lab has demonstrated that combining modified HIV-1 Tat peptide with cationic lipids or polymers dramatically enhanced transfection efficiency without any associated toxicity in vitro and in vivo. Using these novel gene vectors, his lab is investigating whether cancer-induced pain is attenuated by gene therapy. This project is conducted in collaboration with Dr. Brain Schmidt in the Department of Oral and Maxillofacial Surgery at NYU Dentistry. Also, Dr. Yamano's lab is working in collaboration with Dr. Jin Montclare at NYU Polytechnic School of Engineering to develop dual delivery of gene and protein to kill cancer cells using novel engineered protein polymer. In addition, Dr. Yamano's group reported the ability of a collagen membrane to successfully deliver sustained release of several growth factors and the subsequent osteogenic effects of the released factor on bone regeneration. As for molecular study of osseointegration for novel implant surfaces, he has collaboration with Dr. Paulo Coelho in the Department of Biomaterials and Biomimetics at NYU Dentistry.
Complete listing available on the NYU Health Sciences Library site.
Takayama T, Dai J, Tachi K, Shohara R, Kasai H, Imamura K, and Yamano S. The potential of stromal cell-derived factor 1 delivery using a collagen membrane for bone regeneration. J Biomater Appl 31:1049-1061, 2017.
Yamano S, Viet CT, Dang D, Dai J, Hanatani S, Takayama T, Kasai H, Imamura K, Campbell R, Ye Y, Dolan JD, Kwon WM, Schneider SD, and Schmidt BL. Ex vivo non-viral gene delivery of μ-opioid receptor to attenuate cancer-induced pain. Pain 158:240-251, 2017.
More HT, Frezzo JA, Dai J, Yamano S, and Montclare JK. Gene delivery from supercharged coiled-coil protein and cationic lipid hybrid complex. Biomaterials 35: 7188-7193, 2014.
Coelho PG, Takayama T, Yoo D, Jimbo R, Karunagaran S, Tovar N, Janal MN, and Yamano S. Nanometer-scale features on micrometer-scale surface texturing: a bone histological, gene expression, and nanomechanical study. Bone 65:25-32, 2014.
Yamano S, Dai J, Hanatani S, Haku K, Yamanaka T, Ishioka M, Takayama T, and Moursi AM. Efficient in vivo gene delivery using modified Tat peptide with cationic lipids. Biotechnol. Lett. 36:1447-1452, 2014.
Yamano S, Haku K, Yamanaka T, Dai J, Takayama T, Shohara R, Tachi K, Ishioka M, Hanatani S, Karunagaran S, Wada K, and Moursi AM. The effect of a bioactive collagen membrane releasing PDGF or GDF-5 on bone regeneration. Biomaterials 35:2446-2453, 2014.
Yamano S, Dai J, Hanatani S, Haku K, Yamanaka T, Ishioka M, Takayama T, Yuvienco C, Khapli S, Moursi AM, and Montclare JK. Long-term efficient gene delivery using polyethylenimine with modified Tat peptide. Biomaterials 35:1707-1715, 2014.
Keswani SG, Balaji S, Le LD, Leung A, Parvadia JK, Frischer J, Yamano S, Taichman N, and Crombleholme TM. Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing. Wound Repair Regen 21:554-562, 2013.
Yamano S, Kuo WP, and Sukotjo C. Downregulated gene expression of TGF-bs in diabetic oral wound healing. J Craniomaxillofac Surg 41:e42-e48, 2013.
Yamano S, Haku K, Ishioka M, Lin TY, Hanatani S, Dai J, and Moursi AM. The potential of tissue engineering and regeneration for craniofacial bone. Dentistry 2:136, 2012.
Yamano S, Lin TY, Dai J, Fabella K, and Moursi AM. Bioactive collagen membrane as a carrier of sustained release of PDGF. J Tissue Sci Eng 2:110, 2011.
Tsukinoki K, Saruta J, Yamano S, and Tomita M. The salivary gland and systemic health: towards the creation of salivary gland and health medicine. J Oral Biosci 53:330-337, 2011.
Yamano S, Ma AK, Shanti RM, Kim SW, Wada K, and Sukotjo C. The influence of different implant material on human gingival fibroblast morphology, proliferation, and gene expression. Int J Oral Maxillofac Implants 26:1247-1255, 2011.
Yamano S, Al-Sowygh ZH, Gallucci GO, Wada K, Weber HP, and Sukotjo C. Early peri-implant tissue reactions on different titanium surface topographies. Clin Oral Implants Res 22:815-819, 2011.
Yamano S, Dai J, Yuvienco C, Khapli S, Moursi AM, and Montclare JK. Modified Tat peptide with cationic lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis. J Control Release 152:278-285, 2011.
Yamano S, Berley JA, Kuo WP, Gallucci GO, Weber HP, and Sukotjo C. Effects of nicotine on gene expression and osseointegration in rats. Clin Oral Implants Res 21: 1353-1359, 2010.
Yamano S, Dai J, and Moursi AM. Comparison of transfection efficiency of nonviral gene transfer reagents. Mol Biotechnol 46:287-300, 2010.
Berley J, Yamano S, and Sukotjo C. The effect of systemic nicotine on osseointegration of titanium implants in the rat femur. J Oral Implantol 36:185-193, 2010.
Yamano S, Nissenbaum M, Dodson TB, Gallucci GO, and Sukotjo C. Multidisciplinary treatment for a young patient with severe maxillofacial trauma from a snowmobile accident: a case report. J Oral Implantol 36:141-143, 2010.