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Faculty Information

Yu Zhang, PHD

Yu Zhang, PhD

Associate Professor
New York University College of Dentistry
Biomaterials
433 First Avenue, Room 810, New York, NY 10010
Phone: +1-212-998-9637
Fax: +1-212-995-4244
E-mail: yz21@nyu.edu

EDUCATION

PhD, Materials Science, Monash University, Australia 2002

HONORS/CREDENTIALS

  • Outstanding Teacher Award, 2015
  • Arthur R. Frechette Award, 2007
  • Borland Research Forum Award, 1999

RESEARCH INTERESTS / PROFESSIONAL OVERVIEW

  • Development of functionally graded materials for damage resistance, aesthetics, and bioactivities
  • Bio-inspired functionally graded interface design of laminated structures
  • Fatigue behavior of functionally graded ceramics
  • Fractographic analysis of clinically retrieved dental prostheses
  • Mouth-motion fatigue simulation of full-contour restorations
  • Damage initiation and propagation in dental restorations
  • Mechanical reliability and lifetime prediction for biomechanical structures
  • Development of multifunctional calcium phosphate-based bioglass
  • Effects of MZE-CaP compounds on bone properties

CURRENT FUNDING

  1. NIH 2R01 DE017925
    PI. Yu Zhang
    Title: Graded Zirconia Structures for Resistance to Chipping, Delamination, and Fatigue
    Role: Principal Investigator

    The major goal of this competitive renewal proposal aims to further develop zirconia glass graded structures for next-generation all-ceramic dental restorations with improved resistance to chipping, delamination and flexural fracture, as well as improved cementation properties and aesthetics.

  2. NSF DMS-1436591
    PI. Robert Kohn
    Title: Adaptive Fine-Scale Structure Design: From Theory to Fabrication
    Role: Co-Investigator

    The principal goal of the proposed project is to build a bridge between advanced mathematical theory of microstructures, practical computational techniques, and experiment. The outcomes will include parametric families of microstructures, validated with computation, fabrication and experiment, and techniques for using these to solve specific shape optimization problems.

COMPLETED FUNDING

  1. NIH 2R01 AR056208
    PI. Yu Zhang
    Title: Biomaterials (MZF-CaP) for Osteoporosis Prevention, Therapy and Bone Repair
    Role: Principal Investigator (from 01/20/2013)

    The major goal of this project is to develop a safe, affordable calcium phosphate-based compound (MZF-CaP) that will be effective in preventing or recovering bone loss induced by disease (e.g. osteoporosis), therapy (e.g., radiation, steroid) or condition (immobilization, aging).

  2. NSF CMMI-0758530
    PI. Yu Zhang
    Title: Fatigue Behavior of Functionally Graded CeramicsÂľSynthesis, Experiments, and Analysis
    Role: Principal Investigator

    The major goal of this project is to establish the structure-property relationships of functionally graded materials by investigating their fatigue contact, sliding, and flexural damage resistance using a model glass/alumina/glass system.

  3. NIH 1R01 DE017925
    PI. Yu Zhang
    Title: Graded Structures for Damage Resistant All-Ceramic Restorations
    Role: Principal Investigator

    The major goal of this project is to develop an aesthetic, strong, and easy-to-cement zirconia based functionally graded material for less invasive all-ceramic posterior crowns and bridges, foreshadowing possibilities for orthopedic and other engineering applications.

  4. NIH 1R43 AR056167
    PI. Kenneth L. Lambert
    Title: Calcium Phosphate Bone Cement Nanocomposites
    Role: Consultant

    The objective of this project is to develop novel bone cement nanocomposites containing super-strong hydroxyapatite nanofibers. It is hoped that the novel calcium phosphate cement nanocomposites will have excellent biocompatibility and sufficient mechanical properties as a bone implant materials for many orthopedic applications, such as general bone grafts, prosthesis fixation, plateau fracture fixation, vertebroplasty, kyphoplasty, etc.

NYUCD PATENTS

  1. Zhang Y, Kim JW. Thompson VP. Graded Glass/CERAMIC/Glass Structures for Damage Resistant Ceramic Dental and Orthopedic Prostheses. US Patent Number: 8951597. Full patent issued on February 12th, 2015.
  2. Zhang Y, Kim JW. Graded Glass/ZIRCONIA/Glass Structures for Damage Resistant Ceramic Dental and Orthopedic Prostheses. US Patent Number: 8815327. Full patent issued on August 26th, 2014.
  3. Zhang Y, LeGeros RZ, Kim JW. Bioactive Graded Zirconia-Based Structures. US Patent Number: 8703294. Full patent issued on April 22nd, 2014.

REPRESENTATIVE PUBLICATIONS

Complete listing available on the NYU Health Sciences Library site.

  1. Chai H, Kaizer MR, Chughtai A, Tong H, Tanaka CB, Zhang Y, On the Interfacial Fracture Resistance of Resin-Bonded Zirconia and Glass-Infiltrated Graded Zirconia, Dental Materials. Published online: September 10, 2015.
    https://drive.google.com/file/d/0B1B1coCflNHCQjAyTnNtVDlDNlE/view?usp=sharing
  2. Pang Z, Chughtai A, Sailer I, Zhang Y, A Fractographic Study of Clinically Retrieved Zirconia-Ceramic and Metal-Ceramic Fixed Dental Prostheses, Dental Materials, Vol. 31(10), 1198-1206, 2015. PMCID: PMC4575279.
    https://drive.google.com/file/d/0B1B1coCflNHCR0M1UHF1dWZlcnc/view?usp=sharing
  3. Zhang Y. Making Zirconia Translucent, Dental Materials, Vol. 30, pp. 1195-1203, 2014. PMCID: PMC4167579.
    https://drive.google.com/file/d/0B1B1coCflNHCWG9tT3A0b0R1dkk/view?usp=sharing
  4. Ren L, Zhang Y. Sliding Contact Fracture of Dental Ceramics: Principles and Validation, Acta Biomaterialia, Vol. 10, pp. 3243-3253, 2014. PMCID: PMC4065245.
    https://drive.google.com/file/d/0B1B1coCflNHCZ1hFRjhsTVhlSzg/view?usp=sharing
  5. Zhang Y, Sailer I, Lawn BR. Fatigue of Dental Ceramics. Journal of Dentistry, Vol. 41, pp. 1135-1147, 2013. PMCID: PMC3877306.
    https://drive.google.com/file/d/0B1B1coCflNHCY19zUDhTazRVYjQ/view?usp=sharing
  6. Zhang Y, Sun MJ, Zhang D. Designing Functionally Graded Materials with Superior Load-Bearing Properties. Acta Biomaterialia, Vol. 8(3), pp. 1101-1108, 2012. PMCID: PMC3272119.
    https://drive.google.com/file/d/0B1B1coCflNHCWWY4dGhlNG96MDQ/view?usp=sharing
  7. Kim JW, Covel NS, Guess PC, Rekow ED, Zhang Y. Concerns of Hydrothermal Degradation in CAD/CAM Zirconia. Journal of Dental Research, Vol. 89(1), pp.91-95, 2010.
    https://drive.google.com/file/d/0B1B1coCflNHCZnNNN1VoekQ0Mmc/view?usp=sharing
  8. Zhang Y, Kim JW. Graded Structures for Damage Resistant and Aesthetic All-Ceramic Restorations. Dental Materials, Vol. 25(6), pp.781-790, 2009.
    https://drive.google.com/file/d/0B1B1coCflNHCX2ZpaGRIbmVSMmM/view?usp=sharing
  9. Kim JW, Kim JH, Thompson VP, Zhang Y. Sliding Contact Fatigue Damage in Layered Ceramic Structures. Journal of Dental Research, Vol. 86(11), pp.1046-1050, 2007.
    https://drive.google.com/file/d/0B1B1coCflNHCc2xXeldIaUdOcTg/view?usp=sharing
  10. Kim B, Zhang Y, Pines M, Thompson VP. Fracture of Porcelain Veneered Structures in Fatigue. Journal of Dental Research, Vol. 86(2), pp. 142-146, 2007.
    https://drive.google.com/file/d/0B1B1coCflNHCcGZqdHQxc01PQlk/view?usp=sharing
  11. Zhang Y, Song JK, Lawn BR. Deep Penetrating Conical Cracks in Brittle Layers from Hydraulic Cyclic Contact. Journal of Biomedical Materials Research-Part B Applied Biomaterials, Vol. 73B, pp. 186-193, 2005.
    https://drive.google.com/file/d/0B1B1coCflNHCLU50MWlEdWRsalU/view?usp=sharing
  12. Zhang Y, Lawn BR, Rekow ED, Thompson VP. Effect of Sandblasting on the Long-Term Performance of Dental Crowns. Journal of Biomedical Materials Research-Part B Applied Biomaterials, Vol. 71B(2), pp. 381-386, 2004.
    https://drive.google.com/file/d/0B1B1coCflNHCTjJSRHJBSGF6Z0U/view?usp=sharing