Faculty Information
Dane D. Jensen
Assistant Professor
Molecular Pathobiology
Department of Oral & Maxillofacial Surgery
345 E. 24th St
New York, NY 10010
Email: ddj3@nyu.edu
Phone: 212-992-7063
LinkedIn Page
Education
- PhD, Neuroscience, University of Wyoming, Laramie, WY 82072 2011
- BSc, Molecular Biology, University of Wyoming, Laramie, WY 82072 2004
Honors / Credentials (selected)
- Blakemore Award, Columbia University Department of Surgery Research Symposium, 2018, New York, New York.
- New Investigator Award, Council on Hypertension, American Heart Association, 2017, San Francisco California.
- Postdoctoral Poster Award, Winter Conference on Brain Research, February 2015, Big Sky, Montana
- Postdoctoral Presentation Award, Australian Society of Clinical and Experimental Pharmacologists and Toxicologists- and the Molecular Pharmacology of GPCRs Annual meeting, November 2014, Melbourne, Australia
- Neuroscience Outstanding Graduate Student of the Year, May 2008, Laramie, WY
- President, University of Wyoming Neuro/Physiology Club, 2007-2008
Research Interests
Dane D. Jensen is an assistant professor in the NYU Translational Research Center and Department of Molecular Pathobiology. The Jensen lab is investigating the signaling mechanisms of G protein-coupled receptors (GPCRs) in itch, pain, and inflammation. GPCRs are dynamic transmembrane receptors that are involved in most physiological processes. Recent advances in understanding of GPCR signaling have highlighted the ability of GPCRs to signal from endosomes, small membrane bound organelles within cells, once thought only to transport and recycle GPCRs. The ability of GPCRs to signal from endosomes provides greater insight into the relationship between GPCR signaling and disease and has opened a new area for drug discovery. The Jensen lab has shown that GPCR signaling in endosomes is an important factor in sensitization of sensory and interneurons which leads to the development of chronic itch and pain. These discoveries highlight the need to better understand the proteins and mechanisms that regulate intracellular GPCR signaling. The Jensen lab further seeks to understand the mechanisms regulating endosomal GPCR signaling and to develop new therapies to treat pain and itch by targeting endosomal GPCRs.
Publications
Complete listing available on the NYU Health Sciences Library Site.
PubMed Link
Google Scholar Link
Citations: All 911
h-index: All 16
Selected Publications
Endosomal signaling of GPCRs
Ramirez-Garcia PD, Retamal JS, Shenoy P, et al. A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain. Nat Nanotechnol 2019;14:1150-1159.
Jimenez-Vargas NN, Pattison LA, Zhao P, et al. Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome. Proc Natl Acad Sci U S A 2018;115:E7438-E7447.
Jensen DD, Lieu T, Halls ML, et al. Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. Sci Transl Med 2017;9.
Yarwood RE, Imlach WL, Lieu T, et al. Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission. Proceedings of the National Academy of Sciences 2017;114:12309-12314.
Thomsen Alex RB, Plouffe B, Cahill Thomas J, et al. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell 2016;166:907-919.