Dane D. Jensen
- PhD, Neuroscience, University of Wyoming, Laramie, WY 82072 2011
- BSc, Molecular Biology, University of Wyoming, Laramie, WY 82072 2004
Honors / Credentials (selected)
- Blakemore Award, Columbia University Department of Surgery Research Symposium, 2018, New York, New York.
- New Investigator Award, Council on Hypertension, American Heart Association, 2017, San Francisco California.
- Postdoctoral Poster Award, Winter Conference on Brain Research, February 2015, Big Sky, Montana
- Postdoctoral Presentation Award, Australian Society of Clinical and Experimental Pharmacologists and Toxicologists- and the Molecular Pharmacology of GPCRs Annual meeting, November 2014, Melbourne, Australia
- Neuroscience Outstanding Graduate Student of the Year, May 2008, Laramie, WY
- President, University of Wyoming Neuro/Physiology Club, 2007-2008
Dane D. Jensen is a basic research scientist investigating the signaling mechanisms of G protein-coupled receptors in itch, pain, and inflammation. G protein-coupled receptors (GPCRs) are dynamic transmembrane receptors that are involved in most physiological processes. Recent advances in understanding of GPCR signaling have highlighted the ability of GPCRs to signal from endosomes, small membrane bound organelles within cells, once thought to only transport and recycle GPCRs. The ability of GPCRs to signal from endosomes provides greater insight into the relationship between GPCR signaling and disease. GPCR signaling in endosomes is an important factor in the development of chronic pain and itch. The Jensen lab seeks to better understand the mechanisms regulating endosomal GPCR signaling and to develop new therapies to treat pain and itch by targeting endosomal GPCRs.
Endosomal signaling of GPCRs
Ramirez-Garcia PD, Retamal JS, Shenoy P, et al. A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain. Nat Nanotechnol 2019;14:1150-1159.
Jimenez-Vargas NN, Pattison LA, Zhao P, et al. Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome. Proc Natl Acad Sci U S A 2018;115:E7438-E7447.
Jensen DD, Lieu T, Halls ML, et al. Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. Sci Transl Med 2017;9.
Yarwood RE, Imlach WL, Lieu T, et al. Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission. Proceedings of the National Academy of Sciences 2017;114:12309-12314.
Thomsen Alex RB, Plouffe B, Cahill Thomas J, et al. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell 2016;166:907-919.