Faculty Information

David Sirois, DMD, PhD

Associate Professor
Oral and Maxillofacial Pathology, Radiology and Medicine
Room 301 380 Second Avenue
Fax: 646-490-2286
E-mail: david.sirois@nyu.edu

Education

1987 DMD, University of Pennsylvania, School of Dental Medicine
1993 PhD, Biomedical Graduate Group in Neuroscience, University of Pennsylvania

Research Interests / Professional Overview

My basic science research involves investigation of the capacity for the central nervous system to undergo functional and anatomical changes in response to changes in sensory experience, such as following nerve injury, sensory deprivation, and sensory enrichment. I am also interested in exploring intervention strategies which maximize physiological and functional recovery following neural injury. These "plasticity" phenomena have been studied in the rat trigeminal somatosensory system.

Current major efforts are focused on developing (1) clinical research programs which explore the neurophysiology and psychophysical aspects of chronic human pain and intervention strategies to prevent or relieve that pain [This research activity is closely related to my clinical interest in the patient with persistent trigeminal sensory disorders or pain- particularly the role of the nervous system in the initiation and/or maintenance of chronic neuropathic and musculoskeletal pain and (2) conducting pivotal research to develop and evaluate current and emerging diagnostic technologies leading to early detection of oral cancer.

Other research activities focus on basic and clinical investigations related to oral mucosal, salivary gland disorders, and microbiology. This work includes the development of an improved animal model to study radiation-induced salivary gland injury and radioprotection, pharmaceutical / clinical drug trials, immune-mediated salivary gland disease, and oral clinico-pathologic correlates of disease in HIV infection and AIDS.

Current Funding

10/01-9/05 - Oral Cancer Detection; Current and Emerging Technologies (PI: Project #3 of the Research for Adolescent and Ault Health Promotion Center) NIH-NIDCR PI: Dr. David Sirois

6/02-12/03 - Clinical evaluation of a new technique for visualization of squamous lesions of the oral cavity - oral speculoscopy. PI: Dr. Ross Kerr, Co-PI: Dr. David Sirois Sponsor: Trylon Corporation

Representative Publications

Complete listing available on the NYU Health Sciences Library site.

Sirois DA, Miller A, Harwick R, Vonderheid EC. Oral Manifestations of Cutaneous T-Cell Lymphoma. Oral Surgery, Oral Medicine, Oral Pathology 75(6):700-706, 1993

Mooney M, Thomas I, Sirois D. Oral Candidosis. Int J Derm 34(11):759-765, 1995

Touger-Decker R, Sirois, D. Physical Assessment of the Oral Cavity. Support Line 18(5):1-6, 1996.

Sirois D, Wang T, Olaru S, Moheb T. Altered central trigeminal 14C-2-deoxyglucose metabolic activity following ligation of the rat's infraorbital nerve: evidence for central nervous system sensitization. J Dent Res 75:133 (Abstr); 1996

Touger-Decker R. and Sirois DA. Dental Care of the Person with Diabetes. In: (MA Powers, Ed): Handbook of Diabetes Nutritional Management. Pp638-648, Aspen Publishers, Gaithersburg, MD. 1996

Sirois D and Wang T. A painful peripheral trigeminal mononeuropathy with evidence of central nervous system plasticity. Oral Surg Oral Med Oral Path 84(2):160, 1997

Sirois D, Wang T, Greenberg J. Intra-peritoneal injection of a nitric oxide synthase inhibitor increases the responsiveness of vibrissae-related SI cortical neurons. Soc Neurosci Abstr 1997 23(2):2347, 1997

Radfar L, D. Krimsky, and Sirois D. The minipig as an improved animal model for radiation-induced salivary gland injury: a functional and structural study. Oral Surg Oral Med Oral Path 84(2):158, 1997

Krimsky D and Sirois D. Effect of Intradental Capsaicin and IL1-? on Periapical Substance P Immunoreactivity and Neural Proliferation. Oral Surg, Oral Med, Oral Path 85(4): 414, 1998

Sirois D. Oral Manifestations of HIV Infection and AIDS. The Mount Sinai Journal of Medicine 65:322-332, 1998

Fischoff D, Sirois D, Raphael K, Kloser P, Marbach J. Trigeminal neuropathic pain in patients with HIV infection: an interim analysis. 1998 Annual Meeting of the American Pain Society, #822

Sciubba JJ et al (Sirois DA and other members of the Collaborative OralCDx Study Group). The application of computer-assisted analysis of the oral brush biopsy (Oral CDx) for detection of precancerous and cancerous lesions of the oral mucosa. The US Collaborative OralCDx Study Group. JADA 130:1445-1457, 1999

Fatazadeh M, Sirois DA. Chronic erythema multiforme: diagnosis and therapeutic approaches Oral Med Oral Surg Oral Pathol 87:460, 1999

Olaru S, Fischoff D, Sirois DA. Paraneoplastic epidermolysis bullosa acquisita in a patient with multiple myeloma Oral Med Oral Surg Oral Pathol 87:461, 1999

Brown R, Arm R, and Sirois D. The Psychologic Aspects of Chronic Orofacial Pain. In: Brown R, Arm R, and Sirois D (Eds). The Clinicians Guide to the Diagnosis and Treatment of Chronic Orofacial Pain. American Academy of Oral Medicine 1999

Weiner S, Sirois D. Functional responses to implant loading recorded in the mandibular nerve. 15th Annual Meeting of the Academy of Osseointegration, March 9, 2000.

Fatahzadeh M, Kano G, Sirois D and the Consortium for the Prevention and Detection of Oral Cancer. Epidemiologic study of oral mucosal lesions in 1,125 community residents. Oral Surg Oral Med, Oral Path 89(4):442, 2000

Chiang H, Sirois DA, Bielory L. Chronic oral mucosal ulceration in a 54-year old caucasian female. Annals of Allergy, Asthma, & Immunology 84:391-395, 2000

Fatahzadeh M, Roth R, Ettlin D, Sirois D. Diagnostic patterns and delays in pemphigus vulgaris. Oral Surg Oral Med, Oral Path 89(4):444, 2000

Fischoff D and Sirois D. Management of a painful trigeminal compression neuropathy in a patient with systemic sclerosis and severe resorption of the mandible. Oral Surg Oral Med, Oral Path 89(4):453, 2000

Fischoff D, Sirois D. Painful trigeminal neuropathy due to severe mandibular resorption and nerve compression in a patient with systemic sclerosis: case report and review of the literature. Oral Surg Oral Med Oral Path. 90(4):456-459, 2000

Sirois DA, Fatahzadeh M, Roth R, Ettlin D. Diagnostic patterns and delays in pemphigus vulgaris. Archives Dermatology, Arch Dermatol. Dec;136(12):1569-70; 2000

Sirois DA and Gruska M. Parameters of Care: Chemosensory and Neuromuscular Disorders. American Academy of Oral Medicine 2000

Sirois DA, Leigh J, Sollecito TP, Miller A. Forty two cases of oral pemphigus vulgaris preceding cutaneous lesions: Recognition and detection by the dentist. JADA 2000. 131:1156-1160

Chiang H, Sirois DA, Bielory L. Chronic oral mucosal ulceration in a 54-year old caucasian female. Annals of Allergy, Asthma, & Immunology 84:391-395, 2000

Sirois DA, Leigh J, Sollecito TP, Miller A. Forty two cases of oral pemphigus vulgaris preceding cutaneous lesions: Recognition and detection by the dentist. JADA 2000. 131:1156-1160

Sirois DA, Fatahzadeh M, Roth R, Ettlin D. Diagnostic patterns and delays in pemphigus vulgaris. Archives Dermatology, Arch Dermatol. Dec;136(12):1569-70; 2000

Fatahzadeh M, Haghighi K, Milles M, Cleveland D, Sirois D. Multifocal inflammatory jaw lesion in a patient with uncontrolled diabetes: A case report. Oral Surg Oral Med, Oral Path 91(4):421, 2001

Fatahzadeh M, Sirois D. Recurrent intraoral melanoacanthosis: A case report. Oral Surg Oral Med, Oral Path 91(4):421, 2001

Miller C, Epstein J, Hall E, Sirois D. Changing oral care needs in the United States. Oral Surg Oral Med Oral Pathol 91:34-44, 2001

Sirois D and Fatahzadeh M. Medical Update: Valvular Heart Disease. Invited Medical Update Review, Oral Surg Oral Med Oral Pathol. 91:15-19, 2001

Sirois DA, Natelson B. Clinico-Pathological Findings Consistent With Primary Sjogren's Syndrome in a Subset of Patients Diagnosed With Chronic Fatigue Syndrome. J Rheumatology,28:126-31; 2001

Sirois DA, Natelson B. Clinico-Pathological Findings Consistent With Primary Sjogren's Syndrome in a Subset of Patients Diagnosed With Chronic Fatigue Syndrome. J Rheumatology,28:126-31; 2001

Sirois D and Fatahzadeh M. Medical Update: Valvular Heart Disease. Invited Medical Update Review, Oral Surg Oral Med Oral Pathol. 91:15-19, 2001

Miller C, Epstein J, Hall E, Sirois D. Changing oral care needs in the United States. Oral Surg Oral Med Oral Pathol 91:34-44, 2001

Sirois DA. Orofacial Neuralgias and Neuropathic Pain. In: Essential of Oral Medicine, S. Silverman, E. Truelove, R. Eversole and (Eds). BC Decker Inc, Hamilton, Ontario, Canada, 2001

Sirois DA. Non-candidal oral infections eMedicine Journal [serial online]. 2001, Available at eMedicine.

Kuo W, Sirois D, and Pemble C.Locally Aggressive Solitary Fibrous Tumor In The Infraorbital Region: A Case Report and Review of Literature. Oral Surg Oral Med Oral Pathol, 92:308-311, 2002

Fatahzadeh M, Cleveland D, Kano G, Sirois D. Recurrent oral melanoacanthosis: case report and review of the literature. Oral Surg Oral Med Oral Pathol, 94:54-56, 2002

Radfar L, Sirois D A. Structural and functional injury in minipig salivary glands following fractionated exposure to 70Gy of ionizing radiation: an animal model for human radiation-induced salivary gland injury. Oral Surg Oral Med Oral Path. In Press

S. Weiner, H Sapru, D Ehrenberg, B Simon, N Lehrman, H Zohn, D Sirois. Functional responses to implant loading recorded in the inferior alveolar nerve. In Press

Sirois DA "Herpangina" in Fitzpatrick's Dermatology in General Medicine, 6th Ed. Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Eds. McGraw-Hill, New York, NY; 2002, in press