Juhee Jeong, PhD
Basic Science and Craniofacial Biology
345 E. 24th Street, Room 902D, New York, NY 10010
Postdoc, Craniofacial Development, University of California, San Francisco 2010
PhD, Biochemistry, Harvard University 2004
BS, Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST) 1999
- 2017-2022 National Institute of Health Research Project Grant (R01)
- 2015-2016 Whitehead Foundation Fellowship
- 2014-2016 National Institute of Health Small Grant for New Investigators (R03)
- 2014-2015 New York University Research Challenge Fund
- 2013-2014 New York University Goddard Junior Faculty Fellowship
- 2009-2013 National Institute of Health Pathway to Independence Award (K99/R00)
RESEARCH INTERESTS / PROFESSIONAL OVERVIEW
As a developmental biology laboratory, we strive to understand the mechanisms by which cells acquire positional identity within embryonic tissue and thereby develop into a specific part of an organ. In particular, we are investigating the molecular genetic mechanisms behind craniofacial morphogenesis with emphasis on transcriptional regulation. Our laboratory utilizes multidisciplinary approaches including mouse genetics, genomics, biochemistry and molecular biology.
NIH/NIDCR Representative Publications
Complete listing available on the NYU Health Sciences Library site.
Cesario, J.M., Landin Malt, A., Chung, J.U., Khairallah, M.P., Dasgupta, K., Asam, K., Deacon, L.J., Choi, V., Almaidhan, A.A., Darwiche, N.A., Kim, J., Johnson, R.L., and Jeong, J. (2018). Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria. Developmental Biology [Epub ahead of print].
Cesario, J.M., Almaidhan, A., and Jeong, J. (2016). Expression of Forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expression Patterns 20:111-119.
Cesario, J.M., Landin Malt, A., Deacon, L.J., Sandberg, M., Vogt, D., Tang, Z., Zhao, Y., Brown, S., Rubenstein, J.L., and Jeong, J. (2015). Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Human Molecular Genetics 24:5024-5039.
Cesario, J.M., Landin Malt, A., and Jeong, J. (2015). Developmental Genetics of the Pharyngeal Arch System. e-Book. Colloquim Series on Developmental Biology, Vol. 6. Morgan & Claypool Life Sciences.
Bae, C.J., Jeong, J. and Saint-Jeannet, J.P. (2015). A novel function for Egr4 in posterior hindbrain development. Scientific Reports 5:7750.
Landin Malt, A., Cesario, J.M., Tang, Z., Brown, S. and Jeong, J. (2014). Identification of a face enhancer reveals direct regulation of LIM homeobox 8 (Lhx8) by Wingless-Int (WNT)/β-catenin signaling. Journal of Biological Chemistry 289(44):30289-30301. "Best of 2014" in Developmental Biology section of JBC.
Almaidhan, A.*, Cesario, J.*, Landin Malt, A., Zhao, Y., Sharma, N., Choi, V. and Jeong, J. (2014). Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation. BMC Developmental Biology 14:3. *: Equal contributors. Selected for Image of the Month.
Jeong, J.*, Cesario, J., Zhao, Y., Burns, L., Westphal, H. and Rubenstein, J.L.R.* (2012). Cleft palate defect of Dlx1/2-/- mouse mutant is caused by lack of vertical outgrowth in the posterior palate. Developmental Dynamics 241(11):1757-1769. *: Corresponding authors. Winner of Keith and Marion Moore Young Anatomist Publication Award.
Chong, H.J., Young, N.M., Hu, D., Jeong, J., McMahon, A.P., Hallgrimsson, B. and Marcucio, R.S. (2012). Signaling by SHH rescues facial defects following blockade in the brain. Developmental Dynamics 241(2):247-256.
Flandin-Blety, P., Zhao, Y., Vogt, D., Jeong, J., Long, J.E., Westphal, H. and Rubenstein, J.L.R. (2011). Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron 70(5):939-950.
Jeong, J.*, Li, X., McEvilly, R.J., Rosenfeld, M.G., Lufkin, T. and Rubenstein, J.L.R.* (2008). Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development 135(17):2905-2916. *: Corresponding authors.
Chamberlain, C.E., Jeong, J., Guo, C., Allen, B.L. and McMahon, A.P. (2008). Notochord-derived Shh forms a gradient at the basal body of ventral neural progenitors coincident with Shh-dependent specification of distinct cell identities. Development 135(6):1097-1106.
Jeong, J. and McMahon, A.P. (2005). Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the Hedgehog antagonists Patched1 and Hhip1. Development 132(1):143-154.
Tian, H.*, Jeong, J.*, Harfe, B.D., Tabin, C.J. and McMahon, A.P. (2005). Mouse Disp1 is required in Sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 132(1):133-142. *: Equal contribution.
Jeong, J., Mao, J., Tenzen, T., Kottmann, A.H. and McMahon, A.P. (2004). Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes & Development 18(8):937-951.
Charron, F., Stein, E., Jeong, J., McMahon, A.P. and Tessier-Lavigne, M. (2003). The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance. Cell 113(1):11-23.
Jeong, J. and McMahon, A.P. (2002). Cholesterol modification of Hedgehog family proteins. Review. Journal of Clinical Investigation 110(5):591-596.
Jeong, J. and McMahon, A.P. (2001). Vesicles and the spinal cord. News and Views. Nature 412(6843):136-137.