Faculty Information

Karen G. Raphael, PhD

Oral and Maxillofacial Pathology, Radiology and Medicine
Room 301 380 Second Avenue
Fax: 212-992-7130
E-mail: karen.raphael@nyu.edu


Postdoctoral Fellow, Psychiatric Epidemiology, Columbia University 1985-1988
MS, Epidemiology, Columbia University 1988
PhD, Psychology, Hofstra University 1984
MA, Psychology, Hofstra University 1982
BA, Social Sciences, Hofstra University 1977

Research Interests / Professional Overview

  • Psychosocial and psychiatric factors in medically unexplained pain syndromes, including temporomandibular disorders (TMDs) and fibromyalgia.
  • Stress-related disorders
  • Bruxism
  • Empirically-derived diagnostic subgrouping strategies
  • Gene x environment interactions in the pathogenesis of musculoskeletal pain conditions
  • Epidemiological methods/clinical trials

Current Funding

  • Principal Investigator, NIH/NIDCR R01DE018569 [2007-2015] "Sleep Bruxism and Central Sensitization in Myofascial Face Pain"
  • Principal Investigator, NIH/NIDCR R34 DE022464 [2012-2014] "Randomized controlled clinical trial of botulinum toxin for myofascial TMJD Pain"
  • Principal Investigator, NIH/NIDCR R01 DE024522 [2014- ] "Preliminary Safety Study of Botulinum Toxin for Treatment of Myofascial TMJD Pain"

Representative Publications

Search PubMed for articles.

Raphael, K.G. et al. (2014). Osteopenic consequences of botulinum toxin injections in the masticatory muscles: A pilot study. Journal of Oral Rehabilitation, Article first published online: 17 MAY 2014 DOI: 10.1111/joor.12180

Raphael, K.G. et al. (2013). Masticatory muscle sleep background electromyographic activity is elevated in myofascial temporomandibular disorder patients. Journal of Oral Rehabilitation, 40: 883-891.

Raphael, K.G. et al. (2012). Sleep bruxism and myofascial temporomandibular disorder: A laboratory-based polysomnographic investigation. Journal of the American Dental Association, 143: 1209-17.

Raphael, K.G. (2011). External validity and psychiatric disorder exclusions in orofacial pain clinical trials. Journal of Oral Rehabilitation, 38: 785-9.

Raphael, K.G., Widom, C.S. (2011). Post-traumatic stress disorder moderates the relation between documented child abuse and pain 30 years later. Pain. 152: 163-169.

Raphael, K.G., Janal, M.N., Ananthan, S., Cook, DB, Staud, R. (2009). Temporal summation of heat pain in temporomandibular disorder patients. Journal of Orofacial Pain. 23: 54-64

Lavigne, G.J., Khoury, S., Abe, S., Yamaguchi, T., Raphael, K. (2008). Bruxism physiology and pathology: an overview for clinicians. Journal of Oral Rehabilitation. 35:476-494.

Janal, M.N., Raphael, K.G., Nayak, S., Klausner, J.J. (2008). Prevalence of myofascial temporomandibular disorder in U.S. community women. Journal of Oral Rehabilitation.35: 801-809.

Janal, M.N., Raphael, K.G., Klausner, J., Teaford, M. (2007). The role of bruxism in the maintenance of myofascial face pain: A test of alternate models. Pain Medicine. 8:486-496

Raphael KG, Janal MN, Nayak SA, Gallagher RM, Schwartz JE. (2006) Psychiatric comorbidities in a community sample of women with fibromyalgia. Pain, 124:117-125.

Raphael KG, Janal MN, Nayak SA, Gallagher RM, Schwartz JE. Familial aggregation of depression in fibromyalgia: a community-based test of alternate hypotheses. Pain 2004;110:449-460.

Raphael KG, Marbach JJ, Klausner JJ, Teaford MF, Fischoff DK. Is bruxism severity a predictor of oral splint efficacy in patients with myofascial face pain? J Oral Rehabil 2003; 30:17-29.

Marbach JJ, Raphael KG, Janal MN, Hirschkorn-Roth R. Reliability of clinician judgments of bruxism. J Oral Rehabil 2003; 30: 13-118.

Raphael KG, Natelson BH, Janal MN, Nayak S. A community-based survey of fibromyalgia-like pain complaints following the World Trade Center terrorist attacks. Pain 2002; 100:131-9.

Raphael KG, Marbach JJ. Widespread pain and the effectiveness of oral splints in myofascial face pain. J Am Dent Assoc 2001; 132:305-16.

Raphael KG, Widom CS, Lange G. Childhood victimization and pain in adulthood: a prospective investigation. Pain 2001; 92:283-93

Raphael KG, Marbach JJ, Klausner J. Myofascial face pain. Clinical characteristics of those with regional vs. widespread pain. J Am Dent Assoc 2000; 131:161-71.

Dohrenwend BP, Raphael KG, Marbach JJ, Gallagher RM. Why is depression comorbid with chronic myofascial face pain? A family study test of alternative hypotheses. Pain 1999; 83:183-92.

Raphael KG, Marbach JJ, Gallagher RM, Dohrenwend BP. Myofascial TMD does not run in families. Pain 1999; 80:15-22.

Raphael K, Marbach JJ. Evidence-based care of musculoskeletal facial pain: implications for the clinical science of dentistry. J Am Dent Assoc 1997; 128:73-79.