Karen G. Raphael, PhD
Oral and Maxillofacial Pathology, Radiology and Medicine
Room 301 380 Second Avenue
Postdoctoral Fellow, Psychiatric Epidemiology, Columbia University 1985-1988
MS, Epidemiology, Columbia University 1988
PhD, Psychology, Hofstra University 1984
MA, Psychology, Hofstra University 1982
BA, Social Sciences, Hofstra University 1977
Research Interests / Professional Overview
- Psychosocial and psychiatric factors in medically unexplained pain syndromes, including temporomandibular disorders (TMDs) and fibromyalgia.
- Stress-related disorders
- Empirically-derived diagnostic subgrouping strategies
- Gene x environment interactions in the pathogenesis of musculoskeletal pain conditions
- Epidemiological methods/clinical trials
- Principal Investigator, NIH/NIDCR R01DE018569 [2007-2015] "Sleep Bruxism and Central Sensitization in Myofascial Face Pain"
- Principal Investigator, NIH/NIDCR R34 DE022464 [2012-2014] "Randomized controlled clinical trial of botulinum toxin for myofascial TMJD Pain"
- Principal Investigator, NIH/NIDCR R01 DE024522 [2014- ] "Preliminary Safety Study of Botulinum Toxin for Treatment of Myofascial TMJD Pain"
Raphael, K.G. et al. (2014). Osteopenic consequences of botulinum toxin injections in the masticatory muscles: A pilot study. Journal of Oral Rehabilitation, Article first published online: 17 MAY 2014 DOI: 10.1111/joor.12180
Raphael, K.G. et al. (2013). Masticatory muscle sleep background electromyographic activity is elevated in myofascial temporomandibular disorder patients. Journal of Oral Rehabilitation, 40: 883-891.
Raphael, K.G. et al. (2012). Sleep bruxism and myofascial temporomandibular disorder: A laboratory-based polysomnographic investigation. Journal of the American Dental Association, 143: 1209-17.
Raphael, K.G. (2011). External validity and psychiatric disorder exclusions in orofacial pain clinical trials. Journal of Oral Rehabilitation, 38: 785-9.
Raphael, K.G., Widom, C.S. (2011). Post-traumatic stress disorder moderates the relation between documented child abuse and pain 30 years later. Pain. 152: 163-169.
Raphael, K.G., Janal, M.N., Ananthan, S., Cook, DB, Staud, R. (2009). Temporal summation of heat pain in temporomandibular disorder patients. Journal of Orofacial Pain. 23: 54-64
Lavigne, G.J., Khoury, S., Abe, S., Yamaguchi, T., Raphael, K. (2008). Bruxism physiology and pathology: an overview for clinicians. Journal of Oral Rehabilitation. 35:476-494.
Janal, M.N., Raphael, K.G., Nayak, S., Klausner, J.J. (2008). Prevalence of myofascial temporomandibular disorder in U.S. community women. Journal of Oral Rehabilitation.35: 801-809.
Janal, M.N., Raphael, K.G., Klausner, J., Teaford, M. (2007). The role of bruxism in the maintenance of myofascial face pain: A test of alternate models. Pain Medicine. 8:486-496
Raphael KG, Janal MN, Nayak SA, Gallagher RM, Schwartz JE. (2006) Psychiatric comorbidities in a community sample of women with fibromyalgia. Pain, 124:117-125.
Raphael KG, Janal MN, Nayak SA, Gallagher RM, Schwartz JE. Familial aggregation of depression in fibromyalgia: a community-based test of alternate hypotheses. Pain 2004;110:449-460.
Raphael KG, Marbach JJ, Klausner JJ, Teaford MF, Fischoff DK. Is bruxism severity a predictor of oral splint efficacy in patients with myofascial face pain? J Oral Rehabil 2003; 30:17-29.
Marbach JJ, Raphael KG, Janal MN, Hirschkorn-Roth R. Reliability of clinician judgments of bruxism. J Oral Rehabil 2003; 30: 13-118.
Raphael KG, Natelson BH, Janal MN, Nayak S. A community-based survey of fibromyalgia-like pain complaints following the World Trade Center terrorist attacks. Pain 2002; 100:131-9.
Raphael KG, Marbach JJ. Widespread pain and the effectiveness of oral splints in myofascial face pain. J Am Dent Assoc 2001; 132:305-16.
Raphael KG, Widom CS, Lange G. Childhood victimization and pain in adulthood: a prospective investigation. Pain 2001; 92:283-93
Raphael KG, Marbach JJ, Klausner J. Myofascial face pain. Clinical characteristics of those with regional vs. widespread pain. J Am Dent Assoc 2000; 131:161-71.
Dohrenwend BP, Raphael KG, Marbach JJ, Gallagher RM. Why is depression comorbid with chronic myofascial face pain? A family study test of alternative hypotheses. Pain 1999; 83:183-92.
Raphael KG, Marbach JJ, Gallagher RM, Dohrenwend BP. Myofascial TMD does not run in families. Pain 1999; 80:15-22.
Raphael K, Marbach JJ. Evidence-based care of musculoskeletal facial pain: implications for the clinical science of dentistry. J Am Dent Assoc 1997; 128:73-79.