Faculty Information

Nicola C. Partridge, PhD

Professor
Molecular Pathobiology
345 East 24th Street, room 1025B
Phone: 212-992-7145
Fax: 212-995-4204
E-mail: ncp234@nyu.edu


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EDUCATION

PhD, Biochemistry, University of Western Australia, Australia 1981
BSc (Hons), Biochemistry, University of Western Australia, Australia 1973

RESEARCH INTERESTS / PROFESSIONAL OVERVIEW

Dr. Partridge’s research focuses on parathyroid hormone (PTH) regulation of gene expression by the osteoblast. In one project, her laboratory is investigating how PTH, acting through protein kinase A (PKA) signals to the nucleus of osteoblasts to regulate transcription of a gene, receptor activator of nuclear factor kappa B ligand (RANKL), which is involved in activation of osteoclasts and thus, stimulates bone breakdown. In a second project, Dr. Partridge’s laboratory is examining how PKA regulates bone development, mass, and gene expression and its requirement for the anabolic effects of PTH and the new osteoanabolic, abaloparatide. All of this latter project is in vivo in mice.

CURRENT FUNDING

  • Nuclear Events in PTH Action on Bone - NIDDK

REPRESENTATIVE PUBLICATIONS

Complete listing available on the NYU Health Sciences Library site.

Search PubMed for articles.

  1. miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts. Malavika D, Shreya S, Raj Priya V, Rohini M, He Z, Partridge NC, Selvamurugan N. J Cell Physiol. 2020 Jan 21. doi: 10.1002/jcp.29454. [Epub ahead of print] PMID:31960421
  2. Abaloparatide at the Same Dose Has the Same Effects on Bone as PTH (1-34) in Mice. Le Henaff C, Ricarte F, Finnie B, He Z, Johnson J, Warshaw J, Kolupaeva V, Partridge NC. J Bone Miner Res. 2019 Dec 2. doi: 10.1002/jbmr.3930. [Epub ahead of print] PMID:31793033
  3. Parathyroid hormones. Le Henaff, C. and Partridge, N.C. In “Hormonal Signaling in Biology and Medicine” (ed. G. Litwack) Elsevier, San Diego, pp. 507-529, 2019.
  4. Bone proteinases. Nakatani, T. and Partridge, N.C. In "Principles of Bone Biology" (eds. J.P. Bilizekian, T. John Martin, Thomas L. Clemens and Clifford J. Rosen) Academic Press, San Diego, 4th edition, pp. 379-399, 2019.
  5. Parathyroid hormone-stimulation of Runx2 during osteoblast differentiation via the regulation of lnc-SUPT3H-1:16 (RUNX2-AS1:32) and miR-6797-5p. Arumugam B, Vishal M, Shreya S, Malavika D, Rajpriya V, He Z, Partridge NC, Selvamurugan N. Biochimie. 2019 Mar;158:43-52. doi: 10.1016/j.biochi.2018.12.006. Epub 2018 Dec 15. PMID:30562548
  6. Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling. Ricarte FR, Le Henaff C, Kolupaeva VG, Gardella TJ, Partridge NC. J Biol Chem. 2018 Dec 28;293(52):20200-20213. doi: 10.1074/jbc.RA118.004751. Epub 2018 Oct 30. PMID:30377251
  7. Parathyroid hormone-induced down-regulation of miR-532-5p for matrix metalloproteinase-13 expression in rat osteoblasts. Mohanakrishnan V, Balasubramanian A, Mahalingam G, Partridge NC, Ramachandran I, Selvamurugan N. J Cell Biochem. 2018 Jul;119(7):6181-6193. doi: 10.1002/jcb.26827. Epub 2018 Apr 6. PMID:29626351
  8. The Deletion of Hdac4 in Mouse Osteoblasts Influences Both Catabolic and Anabolic Effects in Bone. Nakatani T, Chen T, Johnson J, Westendorf JJ, Partridge NC. J Bone Miner Res. 2018 Jul;33(7):1362-1375. doi: 10.1002/jbmr.3422. Epub 2018 Apr 25. PMID:29544022
  9. Catabolic Effects of Human PTH (1-34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism. Siddiqui JA, Johnson J, Le Henaff C, Bitel CL, Tamasi JA, Partridge NC. Sci Rep. 2017 Nov 10;7(1):15300. doi: 10.1038/s41598-017-15563-7. PMID:29127344
  10. MEF2C Interacts With c-FOS in PTH-Stimulated Mmp13 Gene Expression in Osteoblastic Cells. Nakatani T, Partridge NC. Endocrinology. 2017 Nov 1;158(11):3778-3791. doi: 10.1210/en.2017-00159. PMID:28973134
  11. Pulsed electromagnetic fields inhibit human osteoclast formation and gene expression via osteoblasts. He Z, Selvamurugan N, Warshaw J, Partridge NC. Bone. 2018 Jan;106:194-203. doi: 10.1016/j.bone.2017.09.020. Epub 2017 Sep 28. PMID:28965919
  12. Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation. Selvamurugan N, He Z, Rifkin D, Dabovic B, Partridge NC. Stem Cells Int. 2017;2017:2450327. doi: 10.1155/2017/2450327. Epub 2017 Apr 23. PMID:28512472
  13. CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone. Siddiqui JA, Partridge NC. Front Endocrinol (Lausanne). 2017 Mar 29;8:49. doi: 10.3389/fendo.2017.00049. eCollection 2017. Review. PMID:28424660