Faculty Information

Ryan R. Ruff, MPH, PhD

Associate Professor
Director, MS Program in Clinical Research
Director, Biostatistics Core
Director, Oral Health Epidemiology & Analysis Lab (OHEAL)
Dept. of Epidemiology and Health Promotion
NYU College of Dentistry


Associated Professor
NYU College of Global Public Health

433 First Avenue, Room 712, New York, NY 10010
Phone: 212-998-9663
E-mail: ryan.ruff@nyu.edu


MPH, Epidemiology, Harvard University
PhD, Research, Statistics, & Evaluation, University of Virginia
MPhil, Education, Cambridge University
BAMT, Education, University of Virginia

Honors / Credentials

  • Goddard Junior Faculty Fellowship (2020)
  • Delta Omega Honor Society, Delta Beta Chapter (2018)
  • NYU Academy of Distinguished Educators (2017)
  • Fellow of the Royal Society of Medicine (2016)
  • Member of the New York Academy of Sciences (2015)
  • NYC Department of Health Distinguished Service Award (2012)
  • DuPont Fellowship for Leadership and Policy (2007)

Research Interests / Professional Overview

My work in oral health and child development primarily (though not exclusively) utilizes school-based caries prevention models to study the relationship between oral health, quality of life, and cognitive development. I am currently PI of two large cluster randomized non-inferiority trials of silver diamine fluoride for dental caries and the secondary effects on educational performance and psychosocial functioning. I also study how we can use machine learning and data on the oral microbiome, diet, and hygiene behavior to predict the susceptibility of children to treatment nonresponse. Additional research include the effects of craniofacial surgery on the quality of life of children with cleft and the association between intermittent fasting and oral health.

In addition to my academic appointments, I serve as Director of the MS Program in Clinical Research, Director of the Biostatistics Core, and run the Oral Health Epidemiology and Analysis Lab (OHEAL).

Current Funding

As principal investigator

  • R56DE028933: The role of the oral microbiome in disparities in dental caries and responsiveness to caries prevention ($517,296)
  • R01MD011526: Statewide implementation and evaluation of a rural caries prevention program, 2017-2022 ($3,679,913)
  • PCS-1609-36824: Comparative effectiveness of school-based caries prevention for urban children: A cluster randomized pragmatic clinical trial, 2017-2023 ($13,352,000)
  • R03DE025289: Analysis of longitudinal data from a school-based comprehensive caries prevention program, 2016-2018 ($317,000)

Representative Publications

Complete listing available on the NYU Health Sciences Library site.

Search PubMed for articles.

Ruff RR, Sierra MA, Xu F, Crystal Y, Saxena D. Predicting treatment nonresponse in children receiving silver diamine fluoride using artificial neural networks: A pilot study. medRxiv 2020. doi: 10.1101/2020.10.02.20204743.

Paul B, Sierra MA, Xu F, Crystal Y, Li X, Saxena D, Ruff RR. Microbial population shift and metabolic characterization of silver diamine fluoride treatment failure on dental caries. PLOS One. 2020. doi:10.1101/2020.10.02.20204784.

Ruff RR, Saxena D, Niederman R. School-based caries prevention and longitudinal trends in untreated decay: An updated analysis with Markov chains. BMC Research Notes. 2020;13(1).

Ruff RR, Senthi S, Susser S, Tsutsui A. Oral health, academic performance, and school absenteeism in children and adolescents: A systematic review and meta-analysis. Journal of the American Dental Association 2018; DOI:10.1016/j.adaj.2018.09.023.

Ruff RR. State-level autonomy in the era of accountability: A comparative analysis of Virginia and Nebraska education policy through No Child Left Behind. Education Policy Analysis Archives 2019;26(6):1-31.

Ruff RR. Total observed caries experience: Assessing the effectiveness of community-based caries prevention. Journal of Public Health Dentistry 2018;78(4):287-290.

Ruff RR, Niederman R. Silver diamine fluoride versus therapeutic sealants for the arrest and prevention of dental caries in low-income minority children: Study protocol for a cluster randomized controlled trial. Trials 2018;19(1):523.

Ruff RR, Niederman R. Comparative effectiveness of school-based caries prevention: A prospective cohort study. BMC Oral Health 2018;18(1):53.

Ruff RR, Niederman R. School-based caries prevention, tooth decay, and the community environment. JDR Clinical & Translational Research 2018;3(2):180-187.

Ruff RR, Crerand C, Sawyer D, et al. Surgical care for school-aged youth with cleft: Results from a multicenter, prospective observational study. The Cleft Palate Craniofacial Journal 2018;1(9).

Ruff RR, Sischo L, Broder HL. Development and validation of the Child Oral Health Impact Profile - Preschool version (COHIP-PS). Community Dental Health 2017;34(3):176-182.

Ruff RR, Sischo L, Broder HL. Minimally important difference of the Child Oral Health Impact Profile for children with orofacial anomalies. Health and Quality of Life Outcomes 2016;14(140).

Ruff RR, Broder HL, Sischo L. Resiliency and socioemotional functioning in youth receiving surgery for orofacial anomalies. Community Dentistry and Oral Epidemiology 2016;44(4):371-80.

Ruff RR, Zhen C. Estimating the effects of a calorie-based sugar-sweetened beverage tax on New York City adults using dynamic loss models. Annals of Epidemiology 2015;25(5):350-357.