Faculty Information

Shuang Liang, PhD

Clinical Assistant Professor
Molecular Pathobiology
345 East 24th Street, 9th Floor
New York, NY 10010
E-mail: sl8754@nyu.edu


Ph.D., University of Louisville, KY
M.S., Shandong University, China
B.Sc., Shandong University, China


Dr. Liang received his Ph.D. degree in Immunology from the University of Louisville and Master’s degree in Microbiology from Shandong University in China. Prior to joining NYU College of Dentistry as the director for the D1 Microbiology course, he had served as a faculty member at University of Louisville and Peking University in China. He has many years of teaching and directing experience in Microbiology Lab, Biotechnology Lab, Oral Immunology course, and Oral Health Seminars. Dr. Liang has investigated the oral bacterial infection-induced immune responses and inflammation. His research interests focused on the pathogenesis of oral bacteria, the homeostasis of immune cells and immune responses, and the host-pathogen interactions.  

Representative Publications

  1. Xu W, Zhou W, Wang H, and Liang S. Roles of Porphyromonas gingivalis and its Virulence factors in periodontitis. Advances in Protein Chemistry and Structural Biology, 120: 45-84. 2020
  2. Hays A, Duan X, Zhu J, Zhou W, Upadhyayula S, Shivde J, Song L, Wang H, Su L, Zhou X, Shuang Liang. Down-regulated Treg cells in exacerbated periodontal disease during pregnancy. International Immunopharmacology. 69: 299-306, 2019
  3. Duan X, Hays A, Zhou W, Sileewa N, Upadhyayula S, Wang H, Liang S. Porphyromonas gingivalis induces exacerbated periodontal disease during pregnancy. Microbial pathogenesis. 124:145-151, 2018. PMID: 30118804
  4. Zhou W, Su L, Duan X, Chen X, Hays A, Upadhyayula S, Shivde J, Wang H, Li Y, Huang D, Liang S. MicroRNA-21 down-regulates inflammation and inhibits periodontitis. Molecular immunology. 101:608-614, 2018. PMID: 29884447
  5. Duan X, Gleason RC, Li F, Hosur KB, Duan X, Huang D, Wang H, Hajishengallis G, Liang S. Sex dimorphism in periodontitis in animal models. J Periodontal Res. 51(2): 196-202, 2016
  6. Eskan MA, Jotwani R, Abe T, Chmelar J, Lim JH, Liang S, Ciero PA, Krauss JL, Li F, Rauner M, Hofbauer LC, Choi EY, Chung KJ, Hashim A, Curtis MA, Chavakis T, Hajishengallis G. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nature Immunology. 13(5): 465-473, 2012
  7. Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA. Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement. Cell Host Microbe. 10(5): 497-506. 2011. PMID: 22036469
  8. Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, Li F, Tzekou A, Lambris JD, and Hajishengallis G. The C5a Receptor Impairs IL-12–Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss. The Journal of Immunology, 186(2): 869-877. 2011.
  9. Wang M, Krauss JL, Domon H, Hosur KB, Liang S, Magotti P, Triantafilou M, Triantafilou K, Lambris JD, and Hajishengallis G. Microbial hijacking of complement-toll-like receptor crosstalk. Science Signaling, 3(109): ra11, 2010
  10. Liang S and Hajishengallis G. Heat-labile enterotoxins as adjuvants or anti-inflammatory agents. Immunological Investigations, 39(4-5): 449-467. 2010
  11. Liang S, Hosur KB, Domon H, and Hajishengallis G. Periodontal inflammation and bone loss in aged mice. Journal of Periodontal Research, 45(4): 574-578. 2010.
  12. Liang S, Domon H, Hosur KB, Wang M, and Hajishengallis G. Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mechanisms of Ageing and Development, 130(8): 538-546, 2009
  13. Hajishengallis G, Wang M, and Liang S. Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae. The Journal of Immunology. 182(11): 6690-6696, 2009
  14. Liang S, Hosur KB, Nawar HF, Russell MW, Connell TD, and Hajishengallis G. In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli. Vaccine. 27(32): 4302-4308, 2009
  15. Liang S, Hosur KB, Lu S, Nawar HF, Weber BR, Tapping RI, Connell TD, and Hajishengallis G. Mapping of a Microbial Protein Domain Involved in Binding and Activation of the TLR2/TLR1 Heterodimer. The Journal of Immunology, 182(5): 2978-85, 2009
  16. Hajishengallis G, Wang M, Liang S, Triantafilou M, and Triantafilou K. Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proceedings of the National Academy of Sciences of USA. 105(36): 13532-13537, 2008
  17. Hajishengallis G, Shakhatreh MA, Wang M, and Liang S. Complement Receptor 3 Blockade Promotes IL-12-Mediated Clearance of Porphyromonas gingivalis and Negates Its Virulence In Vivo. The Journal of Immunology, 179(4): 2359-2367, 2007
  18. Liang S, Wang M, Tapping RI, Stepensky V, Nawar HF, Triantafilou M, Triantafilou K, Connell TD, and Hajishengallis G. Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin. Journal of Biological Chemistry, 282(10): 7532-7542, 2007
  19. Liang S, Wang M, Triantafilou K, Triantafilou M, Nawar HF, Russell MW, Connell TD, and Hajishengallis G. The A subunit of type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2. The Journal of Immunology, 178(8), 4811-4819, 2007
  20. Liang S, Alard P, Zhao Y, Clark SL, Parnell S, and Kosiewicz MM. CD4+CD25- cells conversion into CD4+CD25+ regulatory T cells in vivo requires B7 co-stimulation, but not the thymus. Journal of Experimental Medicine, 201(1), 127-137, 2005

Complete List of Published Work can be found in My Bibliography