Basic Science and Craniofacial Biology
Room 901D Dental Center, 421 First Avenue
PhD, Physiology, Rutgers University
MS, Physiology, Chinese Academy of Sciences, Beijing, China
BS, Biology, Shandong University
We are intrigued to investigate the impact of metabolites that function as non-autonomous signals in pathophysiological conditions such as aging and diabetes. Recently, we found that succinate, a TCA cycle metabolite was significantly elevated in mammalian and bacteria exposed to high glucose. Our recent paper in Nature Communications demonstrates that succinate enhances osteoclastogenesis through its receptor Sucnr1 in vitro and in vivo. We will reveal a novel mechanism of succinate and its G-protein coupled receptor (SUCNR1) in osteoclastogenesis, inflammaging and aging-related bone loss.
We have postodotoral positions open, please see below for details:
We are seeking a well-trained researcher with excellent work ethic and the ability to join a NIH-funded group and work on projects to discover the mechanisms that regulate the interaction between microbiome and immune cells under normal and diseased conditions. The primary project is based on our recent finding on succinate stimulated osteoclastogenesis under diabetic condition in Nature Communications (https://www.nature.com/articles/ncomms15621). The applicant is expected to work independently as well as in collaboration with other group members to complete projects in a timely manner.
The candidate should have a PhD in Cell Biology, Biomedical Sciences, or related field. Hands-on experience in molecular biology and cell culture (primary cell culture and differentiation) are required. Familiarity with flow cytometry and FACS cell sorter is highly desirable. Priority will be given to candidates with strong oral communications and writing skills, as evidenced by a strong publication record. In addition to manuscripts, the candidate will be expected to participate in writing animal protocols and research proposals. Competitive salary and benefits commensurate with the candidate's qualifications.
Interested applicants should submit a brief statement of research interests, a CV, and three references to Dr. Xin Li at email@example.com. The position is available immediately (Nov. 2017 until filled).
Preferred specific skills:
Complete listing available on the NYU Health Sciences Library site.
Guo Y, Xie C, Li X, Yang J, Yu T, Zhang R, Zhang T, Saxena D, Snyder M, Wu Y, et al. Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis. Nat Commun. 2017 May 31;8:15621. doi: 10.1038/ncomms15621. PubMed PMID: 28561074; PubMed Central PMCID: PMC5460032.
Yang J, Lu C, Wei J, Guo Y, Liu W, Luo L, Fisch G, Li X. Inhibition of KPNA4 attenuates prostate cancer metastasis. Oncogene. 2017 May 18;36(20):2868-2878. doi: 10.1038/onc.2016.440. Epub 2016 Dec 12. PubMed PMID: 27941876; PubMed Central PMCID: PMC5436935.
Yu T, Wang C, Yang J, Guo Y, Wu Y, Li X. Metformin inhibits SUV39H1-mediated migration of prostate cancer cells. Oncogenesis. 2017 May 1;6(5):e324. doi: 10.1038/oncsis.2017.28. PubMed PMID: 28459432; PubMed Central PMCID: PMC5523061.
Guo Y, Yu T, Yang J, Zhang T, Zhou Y, He F, Kurago Z, Myssiorek D, Wu Y, Lee P, Li X. Metformin inhibits salivary adenocarcinoma growth through cell cycle arrest and apoptosis. Am J Cancer Res. 2015 Nov 15;5(12):3600-11. eCollection 2015.
Li X, Guo Y, Yan W, Snyder MP, Li X. Metformin Improves Diabetic Bone Health by Re-Balancing Catabolism and Nitrogen Disposal. PLoS One. 2015 Dec 30;10(12):e0146152. doi: 10.1371/journal.pone.0146152. eCollection 2015.
Yang J, Wei J, Wu Y, Wang Z, Guo Y, Lee P, Li X. Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer. Oncogenesis. 2015 Jun 15;4:e158. doi: 10.1038/oncsis.2015.18. PubMed PMID: 26075749; PubMed Central PMCID: PMC4491613.
Wei J, Wang Z, Makarov D, Li X. Current treatments and novel therapeutic targets for castration resistant prostate cancer with bone metastasis. Am J Clin Exp Urol 2013 Dec 25;1(1):30-8. eCollection 2013. Review. PubMed PMID: 25374898; PubMed Central PMCID: PMC4219282.
Akinyeke, Tunde; Matsumura, Satoko; Wang, Xinying; Wu, Yingjie; Schalfer, Eric D; Saxena, Anjana; Yan, Wenbo; Logan, Susan K; Li, Xin. Metformin Targets c-MYC Oncogene to Prevent Prostate Cancer. Carcinogenesis. 2013 Dec;34(12):2823-32. doi: 10.1093/carcin/bgt307. Epub 2013 Oct 15. PubMed PMID: 24130167; PubMed Central PMCID: PMC3845895.
Yan W, Li X. Impact of diabetes and its treatments on skeletal diseases. Front Med. 2013 Mar;7(1):81-90. doi: 10.1007/s11684-013-0243-9. Epub 2013 Feb 2. Review. PubMed PMID: 23377889.
Soki FN*, Li X*, Berry J, Koh A, Sinder BP, Qian X, Kozloff KM, Taichman RS, McCauley LK. The effects of zoledronic acid in the bone and vasculature support of hematopoietic stem cell niches, Journal of Cellular Biochemistry, 2012 [Epub ahead of print]. * equal contribution
Pushalkar S, Ji X, Li Y, Estilo C, Yegnanarayana R, Singh B, Li X and Saxena D. Comparison of oral microbiota in tumor and non-tumor tissues of patients with Oral Squamous Cell Carcinoma. BMC Microbiology. 2012 Jul 20;12(1):144.
Park SI, Liao J, Berry JE, Li X, Koh AJ, Michalski MN, Eber MR, Soki FN, Sadler WD, Sud S, Tisdelle SM, Daignault SD, Nemeth JA, Snyder LA, Wronski TJ, Pienta KJ, McCauley LK. Cyclophosphamide Creates a Receptive Microenvironment for Prostate Cancer Skeletal Metastasis. Cancer Research 2012, May 15;72(10):2522-32.
Li X, Liao JH, Koh AJ, Sadler WD, Rosol TJ, Pienta KJ and McCauley LK. Drugs Which Inhibit Osteoclast Function Suppress Tumor Growth through Calcium Decrease in Bone. Bone 2011, 48(6):1354-61 PMID:21419883.
Li X, Koh AJ, Wang Z, Soki FN, Park S, Pienta KJ and McCauley LK. Inhibitory Effects of Megakaryocytic cells in Prostate Cancer Skeletal Metastasis. J Bone Miner Res. 2011 Jan;26(1):125-34.
Li X*, Loberg R*, Liao J, Ying C, Snyder LA, Pienta KJ and McCauley LK. A Destructive Cascade Mediated by CCL2 Facilitates Prostate Cancer Growth in Bone. Cancer Research. 2009 Feb 15;69(4):1685-92 (Highlighted Feature).
Li X, McCauley LK. Osteonecrosis of the jaw: Meeting Report from Skeletal Complications of Malignancy V. IBMS BoneKEy. 2008 Aug;5(8):289-293.
Liao J, Li X, Koh AJ, Berry JE, Thudi N, Rosol TJ, Peinta KJ and McCauley LK. Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions. International Journal of Cancer 2008; Aug 26;123(10):2267-2278.
McCauley LK and Li X. Distinguishing features of the oral cavity and its predisposition to osteonecrosis. J Musculoskelet Neuronal Interact 2007; 7(4): 356-357.