Guttenplan Lab

Molecular Pathobiology
345 East 24th Street, Room 1015-S

Res. Assoc. Professor, Part time
Dept. of Env. Medicine, NYU Medical School


  • Member NIH special emphasis panel (SEP) study section on DNA and protein adducts, 2018.
  • Member Study Section: ZRG1 BST-H (55) December 2017 Meeting Tobacco Regulatory Science.
  • Presidential Nominee for Soc. of Toxicology subsection on carcinogenesis, 2015
  • Invited speaker at 9th International Conference of Anticancer Research, 6-10 October 2014, Sithonia, Greece
  • WTO Scientific Expert on Hormones in Beef in Panel, 2006
  • Member editorial board, Mutation Research, Nutrition and Cancer
  • Air Force Summer Faculty Visiting Scientist, 1996
  • Visiting Scientist, NIH Rocky Mountain Lab, 1988.

Invited speaker at meetings

  • 16th Heidelberger Symposium, NYU College of Medicine, 2007
  • AAAS Southwestern Meeting, 2006
  • Era of Hope, 2005
  • NIH focus group, Cancer Cube, 2002
  • 3rd International Conference on Smokeless Tobacco, 2002
  • 4th Chemical Congress of North America & 202 ACS National Meeting, 1991
  • Mount Sinai Medical Center, Dept of Medicine Minicourse on Enzyme Kinetics, 1985
  • Hoffman LaRoche, Meeting on Inhibition of Carcinogenesis by Vitamins, 1980

Chaired scientific sessions at:

  • American Association for Cancer Research Annual Meeting (2012)
  • the 8th International Conference on Environmental Mutagens (2001)
  • AADR/IADR Annual Meeting (1999)
  • International Environmental Mutagenesis Meeting (1989)
  • the Environmental Mutagen Society National Meeting (1982)

  • Chemical Carcinogenesis and Mutagenesis
  • Induction or enhancement of DNA repair
  • Effects of nutrients on spontaneous and chemically induced mutagenesis in lacI transgenic mice.
  • Effects of nutraceuticals and tobacco on gene expression in human and rodent tissues.
  • Mutagenesis by smokeless tobacco, tobacco components, and tobacco carcinogens in lacZ transgenic mice. 
  • Detection of chemically modified DNA in human oral tissue.
  • Metabolism of tobacco carcinogens by human oral tissue.
  • Development of sensitive fluorescent assays to detect DNA damage.

Research in my laboratory focuses on measuring mutations in tissues of lacZ transgenic mice, and cultured cells, chemoprevention of mutagenesis, development of high sensitivity fluorescence assays for detection of modified nucleotides from DNA, the metabolism of carcinogens, interactions of carcinogens with DNA, detection of carcinogen-DNA adducts, and determination of mutational spectra of carcinogens. Laboratory methodologies include high performance liquid chromatography, mutagenesis, PCR, enzyme assays, gene arrays.

Estee Lauder, Penn State Medical School, University of California, Santa Cruz; Syntax Corp., San Jose, CA; Mount Sinai Medical Center, New York, NY; Dept. of Environmental Medicine, NYU Medical Center Sterling Forest, NY (two different occasions); City College of CUNY, New York, NY (two different occasions); FMC Corp., Trenton, NJ; Hoffman LaRoche, Nutley, NJ; NIH-Rocky Mountain Laboratory, Hamilton, MO; Queens College of CUNY, Queens, NY; York University (Canada), Univ. of Dentistry and Medicine, Newark, New Jersey; Staten Island College of CUNY, Staten Island, NY.

  • NIH grant # R01-CA173465 04/01/2020 – 03/31/ 2020, Effects of black raspberries on oral carcinogenesis, PI.
  • Bioreliance/Sigma-Aldrich 11/1/2016 – present, Production and testing of phage packaging extract, PI.