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Selected Presentations and Publications

  1. Sun, Y-W., Kosinska, W., and Guttenplan, J.B., E-cigarette Aerosol condensate Enhances Metabolism of Benzo(a)pyrene to Genotoxic Products, and Induces CYP1A1 and CYP1B1, Likely by Activation of the Aryl Hydrocarbon Receptor, Int. J. Environ. Res. Public Health, (2019) 16, 2468; doi:10.3390/ijerph16142468.
  2. Joseph B Guttenplan, Kun-Ming Chen, Yuan-Wan Sun, Nora A E Shalaby, Wieslawa Kosinska, Dhimant Desai, Krishne Gowda, Shantu Amin, Karam El-Bayoumy. Effects of the Tobacco Carcinogens N'-Nitrosonornicotine and Dibenzo[ a, l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue, Chem Res Toxicol.. 2019 Sep 16;32(9):1893-1899.
  3. Sun, Yuan-Wan; Chen, Kun-Ming; Atkins, Hannah; Aliaga, Cesar; Gordon, Terry; Guttenplan, Joseph B; El-Bayoumy, Karam. Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice. Chemical research in toxicology. 2021:34(4):1161-1168.DOI: 10.1021/acs.chemrestox.1c00033
  4. Guttenplan, J.B., , Sun, Y-W., Shalaby, N.A.E., Kosinska, W., Desai, D., Gowda, K., Amin,S.,and El-Bayoumy, K., Effects of the Tobacco Carcinogens N′-Nitrosonornicotine and Dibenzo[a,l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue, Chem Res Toxicol 32 (2019).
  5. Chen, K.M., Guttenplan, J.B.,Sun, J.W., Cooper, T., Shalaby, N.A.E., Kosinska, W, Benitez, G. Aliga, C., Zhu, J., Liao, J., Gowda, K, Amin, S., Stoner, G., El-Bayoumy, K., Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis and Tumorigenesis in the Mouse Oral Cavity, Cancer Prev Res (Phila Pa), 11 (2018) 157-164.
  6. El-Bayoumy, K., Chen, S.M. Zhang, Y.W. Sun, S. Amin, G. Stoner and J.B. Guttenplan, Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry, Chem Res Toxicol 30 (2017) 126-144.
  7. Guttenplan, Chen, K.M., Sun, Y.W, Lajara, B.,Shalaby, N.A.E.,Kosinska,W., Benitez, G., Gowda,K., Amin,S., Stoner, G., El-Bayoumy K. Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts, Chem. Res. Toxicol. 30 (2017) 2159-2164.
  8. Guttenplan JB, Sun Y.W, Kosinska W, Zhou Y, Kim S.A, Sung Y, Gowda K, Amin S, Stoner GD, El- Bayoumy K Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells, Cancer Prevention Res. 9 (2016) 704-712.
  9. Chen KM, Guttenplan JB, Zhang SM, Aliaga C, Cooper TK, Sun YW, Deltondo J, Kosinska W, Sharma AK, Jiang K, Bruggeman R, Ahn K, Amin S, El-Bayoumy K., Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: An environmental pollutant and a tobacco smoke constituent. Int J Cancer, 133, 1300-9 (2013) PMID: 23483552.
  10. Sacks, P.G., Zhao, Z.L., Kosinska, W., Fleisher, K, Gordon,T., Guttenplan, J.B., Concentration dependent effects of tobacco particulates from different types of cigarettes on expression of drug metabolizing proteins, and benzo(a)pyrene metabolism in primary normal human oral epithelial cells, Food Chem Toxicol, 49, 2348-55 (2011) PMID: 21722697.
  11. Guttenplan JB, Kosinska W, Zhao ZL, Chen KM, Aliaga C, Deltondo J, Cooper T, Sun YW, Zhang S, Jiang K, Bruggeman R, Sharma AK, Amin S, Ahn K, El-Bayoumy K., Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: A potential new model for oral cancer, Int J Cancer. 130, 2783-90 (2011) PMID: 21815141.
  12. He, Z., Kosinska, W., Zhao, Z.L., Wu, X.R. Guttenplan, J.B., Tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine as the basis for urothelial carcinogenesis, Mutat Res 742 (2012) 92-95.
  13. Diagram illustrating different steps involved in transgenic assays using Big Blue® and gpt-delta mice and rats. The following steps are shown: DNA isolation from target tissues; recovery of infectious λ phage; cII, gpt, and Spi− mutant selection using indicator bacteria; and molecular analysis of target genes from the mutant phages (Fig taken from M. Manjanatha, et al., Genotoxicity Assessment pp 97-119, Methods in Molecular Biology book series (2013).


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