Research

Transgenic Assays using Big Blue® and gpt-delta mice and rats

Diagram illustrating different steps involved in transgenic assays using Big Blue® and gpt-delta mice and rats. The following steps are shown: DNA isolation from target tissues; recovery of infectious λ phage; cII, gpt, and Spi− mutant selection using indicator bacteria; and molecular analysis of target genes from the mutant phages (Fig taken from M. Manjanatha, et al., Genotoxicity Assessment pp 97-119, Methods in Molecular Biology book series (2013).

Transgenic assays using Big Blue® and gpt-delta mice and rats