The gastrointestinal (GI) tract is critical for brain and gut function. We study the roles that the GI tract plays in anxiety and depression, abdominal pain-related disorders of gut-brain interaction, as well as neurodevelopmental disorders.

Margolis Lab

Director, NYU Pain Research Center
Associate Professor, Molecular Pathobiology
NYU College of Dentistry

Associate Professor, Department of Pediatrics
Associate Professor, Department of Cell Biology
NYU Grossman School of Medicine


Our Research

Gut signaling in mood disorders, abdominal pain-related disorders of gut brain interaction and neurodevelopmental disorders.

Our research is focused on discovering the ways in which we can alter gut signaling to treat disorders of the brain and the GI tract.  We have uncovered, and are continuing to reveal, key insights into how gut signaling, involving gut serotonin, nutrition and/or the microbiome, play roles in mood disorders (depression and anxiety), disorders of gut-brain interaction (DGBI; e.g., irritable bowel syndrome) and/or neurodevelopmental disorders, including autism spectrum disorders. We are also developing novel drugs and drug delivery systems to treat brain-gut axis conditions.


Our Team