The Margolis Laboratory studies the roles of gut serotonergic signaling in mood disorders and disorders of gut-brain interaction as well as the role of GI issues in neurodevelopmental disorders.

Margolis Lab

Associate Director, Clinical and Translational Research
Director, Brain-Gut Science
NYU Pain Research Center

Associate Professor, Molecular Pathobiology
NYU College of Dentistry

Associate Professor, Department of Pediatrics
Associate Professor, Department of Cell Biology
NYU Grossman School of Medicine



Kara G. Margolis did her residency in Pediatrics at the Montefiore Medical Center, Albert Einstein College of Medicine and completed a clinical and research fellowship in Pediatric Gastroenterology at Children’s Hospital of Boston, Harvard Medical School.  After completion of her Fellowship training, Dr. Margolis was recruited to Columbia University where she spent 15 years treating children with brain-gut axis disorders, including children with Disorders of Gut-Brain Interaction and also children with Neurodevelopmental Disorders and GI issues. She simultaneously spearheaded a laboratory focused on clinical, translational and basic science research examining diverse aspects of the gut-brain signaling.  This research has provided important insights into how abnormalities in the gut can arise in children with brain-gut axis disorders such as autism, inflammatory bowel diseases, antenatal antidepressant exposure, and disorders of gut-brain interaction. Dr. Margolis was recruited in 2022 to NYU to become the Associate Director for Clinical and Translational Research, and Director of Brain-Gut Science, for an inaugural NYU wide Pain Research Center.

Dr. Margolis’ laboratory is currently funded by the NIH, DoD, Foundations, the pharmaceutical industry and philanthropic donations.

Current research foci:

  • Serotonergic signaling in depression and anxiety
  • Serotonergic signaling in inflammatory bowel diseases
  • Serotonergic signaling in  Disorders of gut-brain interactions and mood
  • The role of GI dysfunction in neurodevelopmental disorders, such as Autism spectrum disorders
  • The role of diet on GI and behavioral outcomes in children with Autism
  • The development of novel drug delivery systems

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