Publications
Selected Publications
Shamsi F, Piper M, Ho LL, Huang TL, Gupta A, Streets A, Lynes MD, Tseng YH. (2021) Vascular smooth muscle-derived TRPV1-expressing progenitors are a source of cold-induced thermogenic adipocytes. Nature Metabolism. 3(4):485-495.
Featured in:
- Nature Metabolism news & views "The genesis of brown fat- a smooth muscle origin story revisited"
- Nature Reviews Endocrinology Research Highlight “Identification of thermogenic adipocyte lineages”.
Angueira AR, Sakers AP, Holman CD, Cheng L, Arbocco M, Shamsi F, Lynes MD, Shrestha R, Okada C, Batmanov K, Susztak K, Tseng YH, Liaw L, Seale P. (2021) Defining the lineage of thermogenic perivascular adipose tissue. Nature Metabolism. 3(4):469-484
Shamsi F, Tseng YH, Kahn CR. (2021) Adipocyte Microenvironment: Everybody in the Neighborhood Talks About the Temperature. Cell Metabolism, 33(1):4-6.
Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, Leiria LO, Shamsi F, Darcy J, Greenwood BP, Narain NR, Tolstikov V, Smith KL, Emanuelli B, Chang YT, Hagen S, Danial NN, Kiebish MA, Tseng YH. (2020) CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine. 26;12(558).
Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan S, Shamsi F, Assaad S, Lin E, Zhang B, Tsai PC, He M, Tseng YH, Lin SJ, and Hsu YC. (2020) Cell types promoting goosebumps form a niche to regulate hair follicle stem cells. Cell, 182, 578–593.
Pirouz M, Wang CH, Liu Q, Ebrahimi AG, Shamsi F, Tseng YHT, Gregory RI. (2020) The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Nature Communications,11(1):2619.
Sato M, Tsuji T, Yang K, Ren X, Dreyfuss JM, Huang TL, Wang CH, Shamsi F, Leiria LO, Lynes MD, Yau KW, Tseng YH. (2020) Cell-autonomous Light Sensitivity via Opsin3 Regulates Fuel Utilization in Brown Adipocytes. PLoS Biology, 18(2):e3000630.
Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO, Lynes MD, Kempf E, Wang CH, Sugimoto S, Nigro P, Landgraf K, Schulz T, Li Y, Emanuelli B, Kothakota S,Williams LT, Jessen N, Pedersen SB, Böttcher Y, Blüher M, Körner A, Goodyear LJ, Mohammadi M, Kahn CR, Tseng YH. (2020) FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nature Communications, 11(1):1421.
Lundh M, Petersen PS, Isidor MS, Kazoka-Sørensen DN, Pluci´nska K, Shamsi F, Ørskov C, Tozzi M, Brown EL, Andersen E, Ma T, Müller U, Barrès R, Kristiansen VB, Gerhart-Hines Z, Tseng YH, Emanuelli B. (2020) Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue. EMBO Reports, 20(8):e48216.
Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. (2019) 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metabolism, 30(4):768-783.
Gupta MK, De Jesus DF, Kahraman S, Valdez IA, Shamsi F, Yi L, Swensen AC, Tseng YH, Qian WJ, Kulkarni RN. (2018) Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation. Molecular Metabolism, 18:153-163.
Lynes MD, Shamsi F, Sustarsic EG, Leiria LO, Wang CH, Su SC, Huang TL, Gao F, Narain NR, Chen EY, Cypess AM, Schulz TJ, Gerhart-Hines Z, Kiebish MA, Tseng YH. (2018) Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. Cell Reports, 24(3):781-790.
Sustarsic EG, Ma T, Lynes MD, Larsen M, Karavaeva I, Havelund JF, Nielsen CH, Jedrychowski MP, Moreno-Torres M, Lundh M, Plucinska K, Jespersen NZ, Grevengoed TJ, Kramar B, Peics J, Hansen JB, Shamsi F, Forss I, Neess D, Keipert S, Wang J, Stohlmann K, Brandslund I, Christensen C, Jørgensen ME, Linneberg A, Pedersen O, Kiebish MA, Qvortrup K, Han X, Pedersen BK, Jastroch M, Mandrup S, Kjær A, Gygi SP, Hansen T, Gillum MP, Grarup N, Emanuelli B, Nielsen S, Scheele C, Tseng YH, Færgeman NJ, Gerhart-Hines Z. (2018) Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metabolism, 28(1):159-174.
Ramirez AK, Lynes MD, Shamsi F, Xue R, Tseng YH, Kahn CR, Kasif S, Dreyfuss JM. (2017) Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes. Cell Reports, 21(11):3040-3048.
Shamsi F, Zhang H, Tseng YH. (2017) MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure. Frontiers in Endocrinology, 8:205.
Mo Q, Salley J, Roshan T, Baer L, May FJ, Jaehnig E, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH. (2017) Anatomical location, gene expression profile, and metabolic characteristics of newly identified mouse supraclavicular brown adipose tissue. JCI Insight, 2(11):e93166.
Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP, Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sudhaharan T, Ishiwata S, Lane EB, Chang YT, Tseng YH, Suzuki M, Raghunath M. (2017) Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes. Scientific Reports, 7(1):1383.
Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Bluher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. (2017) The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nature Medicine, 23(5):631-637.
Shamsi F, Tseng YH. (2017) Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines. Methods Mol Biol, 1566:77-85
Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH. (2015) Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nature Medicine, 21(7):760-8.
Pirouz M, Rahjouei A, Shamsi F, Eckermann K, Salinas-Riester G, Pommerenke C, Kessel M. (2015) Destabilization of pluripotency in the absence of Mad2l2. Cell Cycle, 14(10):1596-610.
Shamsi F, Parlatto R, Collombat P, Mansouri A. (2014) A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells. Cell Cycle, 13(24):3948-57.