Publications
Highlighted Publications
- Nguyen A*, Thomsen ARB*, Cahill III TJ*, Huang R, Huang L-Y, Clarke OB, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little IV J, Chen X, Sunahara R, Steyaert J, Yu Z, des Georges A, Lefkowitz RJ (2019). Structure of an Endosomal Signaling GPCR–G Protein–β-Arrestin Mega-Complex. Nat Struct Mol Biol 26:1123-1131. [*co-first authors]
- Thomsen ARB, Jensen DJ, Hicks GA, Bunnett NW (2018). Therapeutic Targeting of Endosomal GPCRs. Trends Pharmacol Sci 39:879-91.
- Cahill III TJ*, Thomsen ARB*, Tarrasch JT, Plouffe B, Nguyen A, Yang F, Bassoni D, Gavino B, Lamerdin J, Triest S, Huang L-Y, Shukla A, Kahsai AW, Berger B, Little IV J, Antar A, Blanc A, Qu C-X, Chen X, Kawakami K, Inoue A, Aoki J, Steyeart J, Sun J-P, Bouvier M, Skiniotis G, Lefkowitz RJ (2017). Distinct Conformations of GPCR–β-Arrestin Complexes Mediate Desensitization, Signaling and Endocytosis. Proc Natl Acad Sci USA 114:2562-67. [*co-first authors]
- Thomsen ARB*, Plouffe B*, Cahill III TJ*, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L-Y, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ (2016). GPCR–G Protein–β-arrestin Super-Complex mediates Sustained G Protein Signaling. Cell 166:907-19. [*co-first authors]
This publication was highlighted in Trends Biochem Sci and Angew Chem Int Ed, and recommended by Faculty of 1000. - Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill III TJ, Dennison SM, Staus DP, Thomsen ARB, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ (2016). Conformationally Selective RNA Aptamers Allosterically Modulate the β2-Adrenoceptor. Nat Chem Biol 12:709-16.
- Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Thomsen ARB, Zhu X, Kleist A, Costa T, Lefkowitz RJ (2014). Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism at a G Protein-Coupled Receptor (GPCR). J Biol Chem 289:14211-24.
- Jacobsen SE*, Nørskov-Lauritsen L*, Thomsen ARB*, Smajilovic S, Wellendorph P, Larsson NH, Lehmann A, Bhatia VK, Bräuner-Osborne H (2013). Delineation of the GPRC6A Receptor Signaling Pathways using a Mammalian Cell Line Stably Expressing the Receptor. J Pharmacol Exp Ther 347:298-309. [*co-first authors]
- Quinn SJ*, Thomsen ARB*, Pang JL, Kantham L, Bräuner-Osborne H, Pollak M, Goltzman D, Brown EM (2012). Interactions between Calcium and Phosphorus in the Regulation of the Production of Fibroblast Growth Factor 23 In Vivo. Am J Physiol Endocrinol Metab 304:E310-20. [*co-first authors]
- Thomsen ARB, Worm J, Jacobsen SE, Stahlhut M, Latta M, Bräuner-Osborne H (2012). Strontium is a Biased Agonist of the Calcium-Sensing Receptor in Rat Medullary Thyroid Carcinoma 6-23 Cells. J Pharmacol Exp Ther 343:638-49.
- Thomsen ARB, Hvidtfeldt M, Brauner-Osborne H (2011). Biased Agonism of the Calcium-Sensing Receptor. Cell Calcium 51:107-16.