Selected publications of >150 research papers, reviews and chapters


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Bone Metabolism

  1. Yakar S, Werner H, Rosen CJ. Insulin-like growth factors: actions on the skeleton. J Mol Endocrinol. 2018 Jul;61(1):T115-T137. doi: 10.1530/JME-17-0298. Epub 2018 Apr 6. Review. PubMed PMID: 29626053; PubMed Central PMCID: PMC5966339.
  2. Raisingani M, Preneet B, Kohn B, Yakar S. Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis. Growth Horm IGF Res. 2017 Jun;34:13-21. doi: 10.1016/j.ghir.2017.04.003. Epub 2017 Apr 28. Review. PubMed PMID: 28482269; PubMed Central PMCID: PMC5516798.
  3. Yakar S, Isaksson O. Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models. Growth Horm IGF Res. 2016 Jun;28:26-42. doi: 10.1016/j.ghir.2015.09.004. Epub 2015 Sep 28. Review. PubMed PMID: 26432542; PubMed Central PMCID: PMC4809789.

  1. Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7324-9. PubMed PMID: 10377413; PubMed Central PMCID: PMC22084.
  2. Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest. 2002 Sep;110(6):771-81. PubMed PMID: 12235108; PubMed Central PMCID: PMC151128.
  3. Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein M, Majeska RJ, Schaffler MB, Yakar S. Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1). J Bone Miner Res. 2010 Feb;25(2):235-46. doi: 10.1359/jbmr.090723. PubMed PMID: 19619004; PubMed Central PMCID: PMC3153382.
  4. Yakar S, Canalis E, Sun H, Mejia W, Kawashima Y, Nasser P, Courtland HW, Williams V, Bouxsein M, Rosen C, Jepsen KJ. Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. J Bone Miner Res. 2009 Aug;24(8):1481-92. doi: 10.1359/jbmr.090226. PubMed PMID: 19257833; PubMed Central PMCID: PMC2718800.
  5. Courtland HW, Elis S, Wu Y, Sun H, Rosen CJ, Jepsen KJ, Yakar S. Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner. PLoS One. 2011 Mar 18;6(3):e14762. doi: 10.1371/journal.pone.0014762. PubMed PMID: 21445249; PubMed Central PMCID: PMC3060807.
  6. Elis S, Wu Y, Courtland HW, Sun H, Rosen CJ, Adamo ML, Yakar S. Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression. Aging Cell. 2011 Jun;10(3):547-50. doi: 10.1111/j.1474-9726.2011.00683.x. Epub 2011 Mar 22. PubMed PMID: 21418509; PubMed Central PMCID: PMC3094487.
  7. Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S. DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH. FASEB J. 2016 Feb;30(2):635-52. doi: 10.1096/fj.15-275859. Epub 2015 Oct 19. PubMed PMID: 26481310; PubMed Central PMCID: PMC4714547.
  8. Liu Z, Han T, Werner H, Rosen CJ, Schaffler MB, Yakar S. Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass. J Bone Miner Res. 2018 Jan;33(1):123-136. doi: 10.1002/jbmr.3290. Epub 2017 Nov 6. PubMed PMID: 28902430; PubMed Central PMCID: PMC5771972.

Carbohydrate and lipid metabolism

  1. Gong Z, Tas E, Yakar S, Muzumdar R. Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging. Mol Cell Endocrinol. 2017 Nov 5;455:115-130. doi: 10.1016/j.mce.2016.12.022. Epub 2016 Dec 23. Review. PubMed PMID: 28017785.
  2. LeRoith D, Yakar S. Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):302-10. Review. PubMed PMID: 17315038.
  3. Yakar S, Sun H, Zhao H, Pennisi P, Toyoshima Y, Setser J, Stannard B, Scavo L, Leroith D. Metabolic effects of IGF-I deficiency: lessons from mouse models. Pediatr Endocrinol Rev. 2005 Sep;3(1):11-9. Review. PubMed PMID: 16369209.

  1. Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S. Growth Hormone Control of Hepatic Lipid Metabolism. Diabetes. 2016 Dec;65(12):3598-3609. Epub 2016 Sep 27. PubMed PMID: 27679560; PubMed Central PMCID: PMC5127251.
  2. Vijayakumar A, Wu Y, Sun H, Li X, Jeddy Z, Liu C, Schwartz GJ, Yakar S, LeRoith D. Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration. Diabetes. 2012 Jan;61(1):94-103. doi: 10.2337/db11-0814. PubMed PMID: 22187377; PubMed Central PMCID: PMC3237669.
  3. Wu Y, Liu C, Sun H, Vijayakumar A, Giglou PR, Qiao R, Oppenheimer J, Yakar S, LeRoith D. Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. J Clin Invest. 2011 Jun;121(6):2422-6. doi: 10.1172/JCI45027. Epub 2011 May 9. PubMed PMID: 21555853; PubMed Central PMCID: PMC3104750.
  4. Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D. Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. Diabetes. 2004 Nov;53(11):2901-9. PubMed PMID: 15504971.
  5. Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest. 2004 Jan;113(1):96-105. PubMed PMID: 14702113; PubMed Central PMCID: PMC300761.
  6. Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D. Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity. Diabetes. 2001 May;50(5):1110-8. PubMed PMID: 11334415.


  1. Werner H, Lapkina-Gendler L, Achlaug L, Nagaraj K, Somri L, Yaron-Saminsky D, Pasmanik-Chor M, Sarfstein R, Laron Z, Yakar S. Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways. Cells. 2019 Jun 15;8(6). pii: E596. doi: 10.3390/cells8060596. Review. PubMed PMID: 31208077; PubMed Central PMCID: PMC6627189.
  2. Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev. 2007 Feb;28(1):20-47. Epub 2006 Aug 24. Review. PubMed PMID: 16931767.
  3. Yakar S, Leroith D, Brodt P. The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. Cytokine Growth Factor Rev. 2005 Aug-Oct;16(4-5):407-20. Review. PubMed PMID: 15886048.

  1. Wu Y, Brodt P, Sun H, Mejia W, Novosyadlyy R, Nunez N, Chen X, Mendoza A, Hong SH, Khanna C, Yakar S. Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Res. 2010 Jan 1;70(1):57-67. doi: 10.1158/0008-5472.CAN-09-2472. PubMed PMID: 20048072; PubMed Central PMCID: PMC5488282.
  2. Moore T, Carbajal S, Beltran L, Perkins SN, Yakar S, Leroith D, Hursting SD, Digiovanni J. Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. Cancer Res. 2008 May 15;68(10):3680-8. doi: 10.1158/0008-5472.CAN-07-6271. PubMed PMID: 18483250.
  3. Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P. Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. Cancer Res. 2008 May 1;68(9):3342-9. doi:10.1158/0008-5472.CAN-07-3165. PubMed PMID: 18451161; PubMed Central PMCID: PMC2928555.
  4. Zhao H, Cui Y, Dupont J, Sun H, Hennighausen L, Yakar S. Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis. Cancer Res. 2005 Aug 1;65(15):6864-73. PubMed PMID: 16061670.
  5. Wu Y, Cui K, Miyoshi K, Hennighausen L, Green JE, Setser J, LeRoith D, Yakar S. Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res. 2003 Aug 1;63(15):4384-8. PubMed PMID: 12907608.
  6. Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res. 2002 Feb 15;62(4):1030-5. PubMed PMID: 11861378.


  1. Yakar S, Adamo ML. Insulin-like growth factor 1 physiology: lessons from mouse models. Endocrinol Metab Clin North Am. 2012 Jun;41(2):231-47, v. doi: 10.1016/j.ecl.2012.04.008. Epub 2012 May 15. Review. PubMed PMID: 22682628; PubMed Central PMCID: PMC5488279.
  2. Domené HM, Hwa V, Argente J, Wit JM, Camacho-Hübner C, Jasper HG, Pozo J, van Duyvenvoorde HA, Yakar S, Fofanova-Gambetti OV, Rosenfeld RG; International ALS Collaborative Group. Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences. Horm Res. 2009;72(3):129-41. doi: 10.1159/000232486. Epub 2009 Sep 1. Review. Erratum in: Horm Res. 2010;73(1):80. Wit, Jaan M [corrected to Wit, Jan M]. PubMed PMID: 19729943.
  3. Yakar S, Pennisi P, Kim CH, Zhao H, Toyoshima Y, Gavrilova O, LeRoith D. Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models. J Endocrinol Invest. 2005;28(5 Suppl):19-22. Review. PubMed PMID: 16114270.
  4. Yakar S, Pennisi P, Wu Y, Zhao H, LeRoith D. Clinical relevance of systemic and local IGF-I. Endocr Dev. 2005;9:11-16. doi: 10.1159/000085718. Review. PubMed PMID: 15879684.
  5. Yakar S, Kim H, Zhao H, Toyoshima Y, Pennisi P, Gavrilova O, Leroith D. The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting. Pediatr Nephrol. 2005 Mar;20(3):251-4. Epub 2005 Jan 12. Review. PubMed PMID: 15645308.
  6. Yakar S, Wu Y, Setser J, Rosen CJ. The role of circulating IGF-I: lessons from human and animal models. Endocrine. 2002 Dec;19(3):239-48. Review. PubMed PMID: 12624423.
  7. Butler AA, Yakar S, LeRoith D. Insulin-like growth factor-I: compartmentalization within the somatotropic axis? News Physiol Sci. 2002 Apr;17:82-5. Review. PubMed PMID: 11909998.
  8. Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin hypothesis: 2001. Endocr Rev. 2001 Feb;22(1):53-74. Review. PubMed PMID: 11159816.
  9. Yakar S, Liu JL, Le Roith D. The growth hormone/insulin-like growth factor-I system: implications for organ growth and development. Pediatr Nephrol. 2000 Jul;14(7):544-9. Review. PubMed PMID: 10912516.
  10. Liu JL, Yakar S, LeRoith D. Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system. Proc Soc Exp Biol Med. 2000 Apr;223(4):344-51. Review. PubMed PMID: 10721003.


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