Dr. Ye’s laboratory focuses on understanding how peripheral nerves interact with the oral cancer microenvironment to mediate pain as well as tumor progression. To decipher shared molecular and cellular mechanisms underlying cancer progression and pain, her lab combines 2-D and 3-D cell culture, calcium imaging, electrophysiology, microscopy, molecular and genetic manipulations, pharmacology, and behavioral testing in experimental models of oral cancer pain. Understanding the overlapping mechanisms responsible for oral cancer progression and pain may lay the foundation for the development of novel therapeutics for cancer and cancer pain.
Complete listing available on the NYU Health Sciences Library site.
09/30/2022 – 09/29/2025
Treating Oral Cancer Pain with LRP1 Agonists
09/19/2022 – 09/18/2027
Targeting HB-EGF and trigeminal EGFR for oral cancer pain and opioid tolerance
04/01/2020 – 03/31/2025
Schwann cell activation in oral cancer perineurial invasion and neuropathic pain