Current Trials

Do you have oral pre-cancer or cancer?

Seeking volunteers to take part in a study exploring the causes of oral cancer and oral cancer pain

Oral cancer presents a significant health problem. The 5-year survival rate for oral squamous cell carcinoma is 40% and is among the worst of all sites in the body. This survival rate has not improved over the past 40 years. Early detection and treatment profoundly impact survival; however there are currently no genetic markers available to identify pre-cancer and cancer.

The purpose of this study is to find what leads to cancer pain by examining the proteins in blood, saliva, urine, fluid, and tissue produced by oral cancer. This may help doctors to provide very specific therapy for oral cancer and pain. This study will compare the bio-fluids and tissues in oral cancer and oral pre-cancer patients, and healthy volunteers.

Study Details

You may be eligible to participate in this study if you have been recently diagnosed with a suspicious lesion in your mouth, are at least 18 years of age, not pregnant or lactating, and have never previously been treated for head or neck cancer with chemotherapy and/or radiation.

For patients diagnosed with oral cancer who are scheduled for surgery, this study consists of 3 visits over a period of 3 months.

For patients diagnosed with oral pre-cancer and are scheduled for tissue biopsy, this study consists of 2 visits over a period of 2 months.

This study is also recruiting healthy volunteers who are scheduled for teeth extraction or corrective jaw surgery at the NYU College of Dentistry. For this group of participants, this study consists of 1 visit, which will take place at the same time as your scheduled visit to the dental clinic.

Interested in participating?

If you, a family member, or someone you know is interested in this study, please contact our clinical research coordinator at the Translational Research Center at 212-998-9310. We will get back to you as soon as possible. Confidentiality will be maintained for all applicants and participants.

Number of visits: 1–3 days
Start date: 2/1/2001
Duration: 1 day to 3 months
Gender: Male and Female
Ages: 18 and over
Phone number: (212) 998-9310
Status: Currently recruiting

Have you been diagnosed with oral cancer?

Seeking volunteers to take part in research characterizing sensory changes and pain associated with oral cancer

Oral cancer is rapidly increasing in the United States. Squamous cell carcinoma, the most common form of oral cancer, is more painful than all other cancers. The character, severity, and unique features of oral cancer pain differ widely between patients. There is currently no effective and lasting treatment available to treat oral cancer pain.

The purpose of this research is to characterize sensory changes and pain that accompany oral cancer. This may help doctors to provide very specific therapy for oral cancer pain. This research will compare sensory changes in oral cancer patients and healthy volunteers.

Research Details

You may be eligible to participate in this research if you have been recently diagnosed with oral cancer, are at least 18 years of age, not pregnant or lactating, and have never previously been treated for head or neck cancer with chemotherapy and/or radiation. This research is also recruiting healthy volunteers who are at least 18 years of age and not pregnant or lactating.

This research will involve up to two visits, one hour each. You may choose to complete all research procedures in a single visit. During your participation, you will be asked questions about your demographics, medical history, and alcohol use and smoking history as well as have an oral, head and neck exam. You will complete a mechanical sensitivity test and a chemical sensitivity test, which will stimulate your taste buds responsible for detecting spice and bitterness. If you have cancer, you will also be asked to complete a pain questionnaire. You may be asked to return for an optional additional visit to repeat mechanical and chemical sensitivity tests.

Each participant will receive $50.00 for completing the research.

Interested in Participating?

If you, a family member, or someone you know is interested in this research, please contact Dr. Caroline Sawicki (Co-Principal Investigator) at cs6135@nyu.edu or 212-998-9310. We will get back to you as soon as possible.

Confidentiality will be maintained for all participants.

Location

NYU Dentistry Translational Research Center, 421 First Ave., 2nd Floor, New York, NY 10010

Start date: 9/1/2021
Number of Visits: 1-2 days (both visits may be combined into a single day)
Total Duration: 1-2 hours
Compensation: $50.00
Gender: Male and Female
Ages: 18 and over
Status: Currently recruiting

Improving Brain Health During Breast Cancer Therapy

Brief Description

If you are a postmenopausal woman who was diagnosed with breast cancer, you may qualify for this research study. The purpose of this study is to learn whether Mindfulness-Based Stress Reduction or a Health Enhancement Program improves cognitive function (your ability to concentrate and remember things) for women who take aromatase inhibitors. This study will evaluate cognitive function using a brain imaging technique called Magnetic Resonance Imaging (MRI), cognitive tests, and questionnaires. You will be paid up to $250 for completing the study.

Inclusion Criteria

1. Have gone through menopause (are postmenopausal)
2. Are younger than 80 years of age
3. Are diagnosed with stage 0 (DCIS) or stage 1, 2, or 3 breast cancer
4. Are taking an aromatase inhibitor or will be starting it soon

Exclusion Criteria

1. No stage IV (metastatic) breast cancer
2. Not claustrophobic (afraid of being in an MRI machine)
3. No major psychiatric disorder (schizophrenia, bipolar I disorder); no neurological disorder (Parkinson's Disease, dementia); and no head trauma.

Interested in participating?

If you, a family member, or someone you know is interested in this study, please contact our clinical research coordinator Makeda Brown at 212-998-9202 or makeda.culley@nyu.edu. We will get back to you as soon as possible. Confidentiality will be maintained for all applicants and participants.

Number of visits: 11

Duration: 6 months

Gender: Female

Ages: 18–79 years

Phone number: (212) 998-9310

Status: Closed Recruitment

We are currently looking for patients who are about to start radiation or chemoradiation for head and neck cancer.

NYU Dentistry Translational Research Center is currently recruiting patients for a new clinical trial. This study will recruit patients who are about to start radiation or chemoradiation for head and neck cancer. The purpose of the study is to test an oral health regimen to manage oral mucositis.

Study duration: Approximately 4 months
Required visits: Approximately 10
Age of participants: 18+ years
Gender of participants: male and female

Are you experiencing chronic cancer pain even on your current opiate medications?

Battling cancer is its own challenge. But when youre also fighting the chronic or continuing pain associated with cancer, this challenge can be overwhelming. Doctors typically prescribe medicationssuch as morphine or oxycodonefor chronic cancer pain relief; however, even with increased medication dosage, some patients still experience chronic pain.

Study duration: 9 weeks
Required visits: 4
Age of participants: 18 yrs and older years
Gender of participants: male and female

The purpose of this study is to evaluate bone and gum dimension changes around two different type of implants placed.

Implant comparisons placed on 2nd pre-molar or 1st and 2nd molar in the upper jaw

A dental implant is an artificial tooth root placed into your jaw to hold a replacement tooth. Dental implants are an ideal option for people in good general and oral health who have lost a tooth.The study will have three stages: 1) a screening visit, 2) a visit where the dental implants are surgically placed, and 3) implant follow up visits.

Study duration: 12 Months
Required visits: 5
Age of participants: 18 and older years
Gender of participants: male and female

Single visit research study!

You may be eligible to participate in a research study at NYU Dentistry's Translational Research Center to measure tooth shade. You must be at least 11 years old and the visit will lastabout an hour Compensation for your time and travel will be provided.For more information please call Taylor at 212-998-9570 or sjy273@nyu.edu.

Study duration: 1 visit
Required visits: 1
Age of participants: 11+ years
Gender of participants: male and female

The purpose of this research study is to learn about oral health problems that may happen after radiation for head and neck cancer.

Understanding what happens after radiation may help dentists provide better dental care before and after radiation. This research could help future patients who have radiation therapy (RT) for head and neck cancer. It is also possible that no benefit will come from this study.

Study duration: 30 months
Required visits: at least 5
Age of participants: 18 and older years
Gender of participants: male and female

Seeking patients that have received prior treatment for KCOT and have a diagnosis of recurrent KCOT.

Study duration: 3 years
Required visits: up to 20 visits
Age of participants: 18 or older years
Gender of participants: male and female

We are looking for volunteers to participate in a scientific study exploring the effects of spiritual or mystical states of consciousness on anxiety and emotional distress associated with a diagnosis of advanced, recurrent, or potentially current or historical diagnosis of life threatening cancer.

Status: Currently recruiting subjects.
Study duration: 36 weeks
Required visits: Several
Age of participants: 18-76 years
Gender of participants: male and female

The NYU Dentistry Translational Research Center and the NYU Langone Medical Center, funded by the National Cancer Institute are seeking volunteers to take part in a clinical research study. The purpose of this study is to better understand how symptoms.

Status: Currently recruiting subjects.
Study duration: 4-8 weeks
Required visits: 2
Age of participants: 18+ years
Gender of participants: male and female

The purpose of this study is to find out which germs make gum disease worse.

If you are at least 25 years of age, have at least 20 natural teeth, have gum disease, have not used tobacco products for at least a year, you may qualify to participate in a research study at the NYU Dentistry Translational Research Center. This study consists of approximately 14 visits to our study site, over a 21 months period.

Status: Currently recruiting subjects.
Study duration: Approx. 21 month
Required visits: 14
Age of participants: 25+ years
Gender of participants: male and female

The purpose of this study is to evaluate bone and gum dimension changes aroudn two different types of implants placed.

Participants 20 and older who require one single implant (single tooth gap) on in the anterior or pre-molar region of the mandible or maxilla will receive one dental implants and one crown, free of charge, as part of this study. Participants must have adjacent and opposing dentition. Participation will involve 7 visits over one year period.

Status: Currently recruiting subjects.
Study duration: 12 months
Required visits: Approx 7
Age of participants: 18 and older years
Gender of participants: male and female

The propose of this study is to evaluate bone and gum dimension changes around implants placed in different position into the bone.

Status: Currently recruiting subjects.
Study duration: 24 up to 30 months
Required visits: 9-10
Age of participants: 18-older years
Gender of participants: male and female